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HCV co-infection is associated with metabolic abnormalities among HAART naïve HIV-infected persons
Objectives: To determine the metabolic abnormalities among Hepatitis C Virus (HCV) coinfected HAART naïve HIV infected persons within the adult ARV clinic of the University College Hospital/University of Ibadan, Ibadan, Nigeria Methods: This was a retrospective study involving the review of clinical...
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| Format: | Article |
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2017
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/8769 | ||
| 042 | |a dc | ||
| 720 | |a Kuti, M. A. |e author | ||
| 720 | |a Akinyemi, J. O. |e author | ||
| 720 | |a Ogunbosi, B. O. |e author | ||
| 720 | |a Kuti, K. M. |e author | ||
| 720 | |a Adesina, O. A. |e author | ||
| 720 | |a Awolude, O. A. |e author | ||
| 720 | |a Michael, O. S. |e author | ||
| 720 | |a Adewole, I. F. |e author | ||
| 260 | |c 2017 | ||
| 520 | |a Objectives: To determine the metabolic abnormalities among Hepatitis C Virus (HCV) coinfected HAART naïve HIV infected persons within the adult ARV clinic of the University College Hospital/University of Ibadan, Ibadan, Nigeria Methods: This was a retrospective study involving the review of clinical records of newly recruited HIV-infected persons in the adult antiretroviral (ARV) clinic over a 12month period (January - December 2006). Baseline results for fasting plasma glucose (FPG) and fasting lipid profile were retrieved. Results: Out of the 1,260 HIV infected persons seen during the study period, HCV co-infection was found in 75 (6%) persons. The median values for total cholesterol, LDL-cholesterol and HDLcholesterol were lower in the HCV co-infected persons. HIV-HCV co–infection was associated with a 0.31 mmol/L depression in Total Cholesterol (TC). The median FPG concentration was significantly higher in HIV-HCV co–infected than HIV only infected persons (5.33mmol/L vs. 5.00mmol/L, p = 0.047). However, regression analysis showed there was no relationship between the HIV-HCV coinfected State and fasting glucose levels. Conclusion: HIV-HCV co-infection may be associated with a predictable decline in plasma cholesterol, but FPG may not be sufficient to demonstrate insulin resistance in these persons. | ||
| 024 | 8 | |a ui_art_kuti_hcv_2017 | |
| 024 | 8 | |a Nigerian Journal of Clinical Practice 20, pp. 799-803 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/8769 | |
| 653 | |a HCV | ||
| 653 | |a HIV | ||
| 653 | |a Metabolic abnormalities | ||
| 245 | 0 | 0 | |a HCV co-infection is associated with metabolic abnormalities among HAART naïve HIV-infected persons |