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The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation bet...
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| Format: | Article |
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2002-09
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/916 | ||
| 042 | |a dc | ||
| 720 | |a Nwuba, R. I. |e author | ||
| 720 | |a Sodeinde, O. |e author | ||
| 720 | |a Anumudu, C. I. |e author | ||
| 720 | |a Omosun, Y. O. |e author | ||
| 720 | |a Odaibo, A. B. |e author | ||
| 720 | |a Holder, A. A. |e author | ||
| 720 | |a Nwagwu, M. |e author | ||
| 260 | |c 2002-09 | ||
| 520 | |a Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines. | ||
| 024 | 8 | |a 1098-5522 | |
| 024 | 8 | |a Infection and Immunity 70(9), pp. 5328-5331 | |
| 024 | 8 | |a ui_art_nwuba_human_2002 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/916 | |
| 245 | 0 | 0 | |a The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies |