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Sporothrix schenckii and its possible origins in South Africa
Dissertation (MSc (Genetics))--University of Pretoria, 2025.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2025
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| _version_ | 1867613704270381056 |
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| access_status_str | Open Access |
| author2 | Wingfield, Brenda D. |
| author_browse | Wingfield, Brenda D. |
| author_facet | Wingfield, Brenda D. |
| collection | Thesis |
| dc_rights_str_mv | © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Genetics))--University of Pretoria, 2025. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/101863 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:22.637Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/101863 Sporothrix schenckii and its possible origins in South Africa Wingfield, Brenda D. taygen.fuchs@up.ac.za Wingfield, Michael J. Visagie, Cobus Fuchs, Taygen UCTD Sustainable Development Goals (SDGs) Sporotrichosis Sporothrix Mycoses Genetic diversity Gold mines Dissertation (MSc (Genetics))--University of Pretoria, 2025. Sporothrix is a genus of dimorphic fungi primarily associated with environmental habitats, though several species also cause infections in mammals. This subcutaneous infection is typically transmitted through trauma to the skin and can lead to chronic and debilitating disease. The global health implications of Sporothrix are significant, with the disease increasingly recognised as an emerging concern, particularly due to the current epidemic in South America. In South Africa, sporotrichosis holds a unique epidemiological significance, with large outbreaks in the gold mining industry previously recorded. Despite the epidemiological significance of pathogenic Sporothrix in South Africa, little is known about the species diversity and genetic variation of these pathogens in the country. This study aimed to address key ecological and epidemiological questions, particularly focusing on elucidating the environmental ecology and diversity of these pathogens in South Africa. Investigation into the presence of Sporothrix in samples collected from gold mine substrates, revealed an untapped reservoir of biodiversity in the gold mine environment. Recently developed molecular markers were applied to a population of Sporothrix species isolated from clinical samples from across South Africa. This revealed surprising species and genetic diversity among the clinical isolates, further allowing for the distribution of Sporothrix lineages across the country to be elucidated. Department of Science and Innovation (DSI), through the NRF-SARChI chair in fungal genomics held by Prof. Brenda Wingfield. Biochemistry, Genetics and Microbiology (BGM) MSc (Genetics) Unrestricted Faculty of Natural and Agricultural Sciences SDG-03: Good heath and well-being SDG-15:Life on land 2025-04-03T07:49:54Z 2025-04-03T07:49:54Z 2025-09 2025-02 Dissertation * S2025 http://hdl.handle.net/2263/101863 https://doi.org/10.25403/UPresearchdata.28407878 en © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Sustainable Development Goals (SDGs) Sporotrichosis Sporothrix Mycoses Genetic diversity Gold mines Sporothrix schenckii and its possible origins in South Africa |
| title | Sporothrix schenckii and its possible origins in South Africa |
| title_full | Sporothrix schenckii and its possible origins in South Africa |
| title_fullStr | Sporothrix schenckii and its possible origins in South Africa |
| title_full_unstemmed | Sporothrix schenckii and its possible origins in South Africa |
| title_short | Sporothrix schenckii and its possible origins in South Africa |
| title_sort | sporothrix schenckii and its possible origins in south africa |
| topic | UCTD Sustainable Development Goals (SDGs) Sporotrichosis Sporothrix Mycoses Genetic diversity Gold mines |
| url | http://hdl.handle.net/2263/101863 https://doi.org/10.25403/UPresearchdata.28407878 |