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Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020
Thesis (PhD)--University of Pretoria, 2024.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2025
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| _version_ | 1867613665443708928 |
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| access_status_str | Open Access |
| author2 | Quan, Melvyn |
| author_browse | Quan, Melvyn |
| author_facet | Quan, Melvyn |
| collection | Thesis |
| dc_rights_str_mv | © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2024. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/103599 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:45.647Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/103599 Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 Quan, Melvyn frank.banda@sacids.org Lebea, Phiyani Banda, Frank UCTD Sustainable Development Goals (SDGs) Foot-and-mouth disease (FMD) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (FMDV) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (Aphthovirus vesiculae) Zambia Epidemiology Thesis (PhD)--University of Pretoria, 2024. Repeated outbreaks of transboundary animal diseases, particularly foot-and-mouth disease (FMD), have posed significant challenges to the development of the livestock industry in Zambia and the broader Southern African region. This sector is crucial to national food security and livelihoods and holds potential for greater economic contribution due to Zambia’s favourable natural resources. This study explores the molecular epidemiology of the FMD virus (FMDV) in Zambia, focusing on the emergence and spread of serotypes O/EA-2, A, SAT-2, and SAT-3. A scoping review of diagnostic assays for SAT serotypes recommended the combined use of SAT-1, SAT-2, and SAT-3 lateral flow devices (LFDs) for effective viral detection, with the PrioCheck®-NSP kit proving highly effective for non-structural protein antibody identification. The immunogenicity of the O-Manisa vaccine was assessed in cattle challenged with the O/EA-2 outbreak strain, revealing significantly higher antibody titres in double-dosed animals at 56 days post-vaccination (dpv) compared to single-dosed groups. Furthermore, a strong positive correlation was observed between virus neutralisation tests and solid-phase competitive ELISA (SPCE), supporting the use of SPCE in immunogenicity assessments, particularly in resource-constrained settings. The findings underscore the complexity of FMD epidemiology in Zambia and highlight the urgent need for continuous monitoring of serotype O/EA-2 and a coordinated regional strategy for FMD control across Southern Africa. Veterinary Tropical Diseases PhD (Veterinary Tropical Diseases) Unrestricted Faculty of Veterinary Science SDG-02: Zero Hunger SDG-15: Life on land 2025-07-25T09:15:34Z 2025-07-25T09:15:34Z 2025-09 2024-10 Thesis * S2025 http://hdl.handle.net/2263/103599 https://doi.org/10.25403/UPresearchdata.29636999 en © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Sustainable Development Goals (SDGs) Foot-and-mouth disease (FMD) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (FMDV) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (Aphthovirus vesiculae) Zambia Epidemiology Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title | Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title_full | Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title_fullStr | Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title_full_unstemmed | Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title_short | Characterisation and control of foot-and-mouth disease outbreaks in Zambia between 2015 and 2020 |
| title_sort | characterisation and control of foot and mouth disease outbreaks in zambia between 2015 and 2020 |
| topic | UCTD Sustainable Development Goals (SDGs) Foot-and-mouth disease (FMD) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (FMDV) Foot-and-mouth disease virus (renamed Aphthovirus vesiculae) (Aphthovirus vesiculae) Zambia Epidemiology |
| url | http://hdl.handle.net/2263/103599 https://doi.org/10.25403/UPresearchdata.29636999 |