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Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats
Dissertation (MScAgric (Animal Breeding & Genetics))--University of Pretoria, 2016.
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| Format: | Thesis |
| Language: | English |
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2026
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| _version_ | 1867613515407163392 |
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| access_status_str | Open Access |
| author2 | Visser, Carina |
| author_browse | Visser, Carina |
| author_facet | Visser, Carina |
| collection | Thesis |
| description | Dissertation (MScAgric (Animal Breeding & Genetics))--University of Pretoria, 2016. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/110054 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:22.574Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/110054 Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats Visser, Carina maruschkeandrews@gmail.com Van Marle-Köster, Este Andrews, Maruschke Mohair Polymorphism Heterozygosity Dissertation (MScAgric (Animal Breeding & Genetics))--University of Pretoria, 2016. Mohair is a high quality sought-after animal fibre with South Africa being the largest producer worldwide. Keratin and keratin associated proteins are the primary components that determine the quantitative and qualitative characteristics of these hair fibres, such as fibre diameter. Molecular based research on Angora goats in South Africa to date has focused on application of DNA markers for population genetics and identification of quantitative trait loci. The aim of this study was to use DNA sequencing technology to study three keratin associated proteins not yet investigated in South African Angora goats. Three keratin associated protein genes, namely KAP 1.1, KAP 8.1, and KAP 13.3, were studied in 108 goats representing three populations, namely Angora, Boer goat, and AngoraXBoer crossbred goat (AB crossbred). DNA was extracted from whole blood and subjected to PCR and sequencing analyses. The alleles identified were also investigated for diversity within the three different populations. All three genes were found to be highly polymorphic with seven new alleles identified for KAP 1.1, based on a combination of five different SNP positions. Four alleles were identified for KAP 8.1, based on a combination of two SNP positions. One KAP 8.1 allele, allele D, was a new allele found only in Boer goats. KAP 13.3 was the most polymorph, with a total of 18 alleles identified, of which 11 were newly identified, namely alleles I to S. KAP 13.3 alleles were formed by a combination of 17 SNP positions, some of which appeared to be inherited as a haplotype. Preliminary results indicate specific allelic variation for the different populations, with different secondary protein structures for different alleles. Angora goats were the most diverse for each of the genes investigated, and Boer goats the least diverse. Further studies are required to confirm phenotypic associations of these genes that may assist in more accurate selection of goats with superior hair quality Animal and Wildlife Sciences MScAgric (Animal Breeding & Genetics) 2026-05-15T17:26:10Z 2026-05-15T17:26:10Z 16/10/05 2016 Dissertation http://hdl.handle.net/2263/110054 en application/pdf |
| spellingShingle | Mohair Polymorphism Heterozygosity Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title | Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title_full | Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title_fullStr | Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title_full_unstemmed | Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title_short | Molecular characterization and polymorphism of three keratin associated protein genes in South African Angora goats |
| title_sort | molecular characterization and polymorphism of three keratin associated protein genes in south african angora goats |
| topic | Mohair Polymorphism Heterozygosity |
| url | http://hdl.handle.net/2263/110054 |