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Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis
Dissertation (MRAD (Radiography))--University of Pretoria, 2015.
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| Format: | Thesis |
| Language: | English |
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2026
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| _version_ | 1867613707667767297 |
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| access_status_str | Open Access |
| author2 | Sathekge, Mike Machaba |
| author_browse | Sathekge, Mike Machaba |
| author_facet | Sathekge, Mike Machaba |
| collection | Thesis |
| description | Dissertation (MRAD (Radiography))--University of Pretoria, 2015. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/110056 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:25.890Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/110056 Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis Sathekge, Mike Machaba margueritemeintjies@gmail.com Dickson, J. Makanjee, Chandra Rekha Du Preez Meintjes, Marguerite Myocardial blood flow coronary flow reserve coronary stenosis positron emission tomography Dissertation (MRAD (Radiography))--University of Pretoria, 2015. Background Non-invasive imaging of the coronary arteries has been challenging because of limited and contradictory reviews about clinical utility. PET myocardial perfusion imaging is a standard technique for assessing myocardial function, but provides limited information on the anatomy of cardiac structures. Coronary artery calcium score on the other hand provide information on calcified plaque burden and the anatomical structure of the coronary arteries. The aim of this study was to determine the relationship between quantitative myocardial blood flow, coronary artery calcium and coronary artery disease. This work also aims to determine whether MBF quantification and/or CAC add value to relative MPI, and aid in the reclassification of patients with Coronary artery disease. This way a ‘gatekeeper’ study could be identified to predict coronary artery stenosis and improve our clinical service. Method An experimental study design was used to measure the relationship of the percentage of coronary artery stenosis versus myocardial blood flow, and also the coronary calcium, with an analytical study design to test the hypothesis by comparing 82Rb blood flow to the calcium score values to determine the value of adding these imaging modalities to relative MPI. 120 patients (77male, 43 female) with suspected or known CAD who underwent clinical 82Rb PET/CT MPI, calcium score and CT coronary angiography imaging were included in this study. The presence of ischaemia was assessed from qualitative reporting of 82Rb MPI. Using the same data, quantitative values of MBF and coronary flow reserve were derived. Calcium score images were quantitatively analyzed and categorized into 3 groups defined by CAC values of 0, 1-400 and ≥400. Significant stenosis was classified as stenosis of ≥50% on CT angiography. Results Statistical analysis was performed by Prof P Rheeder from the Department of Internal Medicine at the University of Pretoria. For the first part of the study an experimental research design was used to determine the relationship between myocardial blood flow, coronary artery calcium and the percentage stenosis in the coronary arteries. Various packages in R and STATA were used to analyse data with ordinal logistic regression tests and frequency tables with chi square tests for ix trends and odds ratios. For the second part of the study an analytical study design was used to determine the value of adding quantitative myocardial blood flow to visual only assessment of myocardial perfusion imaging and the impact of adding calcium score imaging. Once again various packages in R and STATA were used for the analysis of data to determine ROC curves, increased prediction and the net reclassification index. Our results showed an inverse correlation between stress MBF and the percentage stenosis as well as an inverse correlation when compared to CAC, which led to an inverse correlation between CFR and the percentage stenosis and CAC in patients with a moderate likelihood of CAD. Secondly we observed a direct correlation between CAC and the percentage stenosis, indicating that an increase in coronary calcification in individual coronary arteries is related to the severity of the coronary stenosis. These results helped us to prove that the addition of stress MBF to relative MPI (32%) resulted in a significantly higher sensitivity (48%, p=0.002) which was significantly more increased with the addition of CFR (58%, p Radiography MRAD (Radiography) 2026-05-15T17:26:11Z 2026-05-15T17:26:11Z 15/09/17 2015 Dissertation http://hdl.handle.net/2263/110056 en application/pdf |
| spellingShingle | Myocardial blood flow coronary flow reserve coronary stenosis positron emission tomography Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title | Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title_full | Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title_fullStr | Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title_full_unstemmed | Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title_short | Comparison of 82Rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| title_sort | comparison of 82rubidium myocardial blood flow quantification with coronary calcium score for prediction of coronary artery stenosis |
| topic | Myocardial blood flow coronary flow reserve coronary stenosis positron emission tomography |
| url | http://hdl.handle.net/2263/110056 |