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Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle
Dissertation (MMedVet (Pathology))--University of Pretoria, 2004.
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University of Pretoria
2013
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| _version_ | 1867613466582319104 |
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| access_status_str | Open Access |
| author2 | Prozesky, Leon |
| author_browse | Prozesky, Leon |
| author_facet | Prozesky, Leon |
| collection | Thesis |
| dc_rights_str_mv | © 2004, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet (Pathology))--University of Pretoria, 2004. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/23005 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:36:35.732Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/23005 Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle Prozesky, Leon Botha, C.J. (Christoffel Jacobus) info@vetpath.co.za Du Plessis, Elizabeth C. Cattle Nolletia gariepina Plant poisoning Kalahari sandveld Kidney UCTD Dissertation (MMedVet (Pathology))--University of Pretoria, 2004. The first recorded outbreak of nephrotoxicosis induced by the shrub Nolletia gariepina is reported. The outbreaks occurred in cattle in the Kalahari sandveld of South Africa. The toxicosis was experimentally reproduced, initially in a steer, as a pilot trial to confirm toxicity of the plant material, and thereafter in two other cattle. Toxicity was induced by intraruminal administration of 3 g/kg dried, milled plant material as a single dose. The animals had to be starved for 24 hours before dosing, as dosing on a full rumen did not induce any signs of toxicity during five days of observation and clinical pathology monitoring. In both the field outbreaks and the experimental toxicological trial, clinical signs were not specific and varied according to the duration (acute versus subacute) of the toxicological process. Clinical pathological parameters in the experimental cases indicated renal and, to a lesser extent, hepatic damage, with raised serum concentrations of urea, creatinine, aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT). Increased urinary sodium and potassium concentration and GGT activity, as well as proteinuria, were evident. The histological and electron microscopical examinations revealed acute renal tubular epithelial cell degeneration and necrosis, especially of the proximal convoluted tubules. Mild hepatocellular degeneration was also noticeable. Paraclinical Sciences unrestricted 2013-09-06T14:19:19Z 2005-03-08 2013-09-06T14:19:19Z 2004-02-28 2006-03-08 2005-03-08 Dissertation Du Plessis, E 2004, Pathological investigation of the nephrotoxic effects of the Shrub Nolletia Gariepina (DC) Mattf. in cattle, MMedVet dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/23005 > http://hdl.handle.net/2263/23005 http://upetd.up.ac.za/thesis/available/etd-03082005-103634/ © 2004, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Cattle Nolletia gariepina Plant poisoning Kalahari sandveld Kidney UCTD Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title | Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title_full | Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title_fullStr | Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title_full_unstemmed | Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title_short | Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle |
| title_sort | pathological investigation of the nephrotoxic effects of the shrub nolletia gariepina dc mattf in cattle |
| topic | Cattle Nolletia gariepina Plant poisoning Kalahari sandveld Kidney UCTD |
| url | http://hdl.handle.net/2263/23005 http://upetd.up.ac.za/thesis/available/etd-03082005-103634/ |