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Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance
Dissertation (MSc)--University of Pretoria, 2010.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613695651086336 |
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| access_status_str | Open Access |
| author2 | Stefan, Raluca-Ioana |
| author_browse | Stefan, Raluca-Ioana |
| author_facet | Stefan, Raluca-Ioana |
| collection | Thesis |
| dc_rights_str_mv | © 2005, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2010. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/23024 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:40:14.504Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/23024 Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance Stefan, Raluca-Ioana s25491599@tuks.co.za Holo, Luxolo Potentiometric membrane electrodes Enantiomers Chromatographic techniques UCTD Dissertation (MSc)--University of Pretoria, 2010. The enantioanalysis of compounds of clinical and pharmaceutical became increasingly important because the enantiomers of the same substance may be markers for different disease or are having a different pathway in the body. The utilization of enantioselective, potentiometric membrane electrodes made the assay of a single enantiomer easier and faster. Also the reliability of the analytical information is higher than that obtained using chromatographic techniques. The proposed electrodes are made by mixing graphite powder with paraffin oil to give carbon paste, which is modified by the addition of a chiral selector (e.g., cylodextrins, maltodextrins, macrocyclic antibiotics and fullerenes). This design is reliable. The high sensitivity, selectivity, enantioselectivity, accuracy and precision made them suitable to be used for the enantioanalysis of different compounds of clinical and pharmaceutical importance (e.g., L-histidine, L-cysteine and R-clenbuterol) in pharmaceutical tablets, and/or serum and urine samples. Copyright Chemistry unrestricted 2013-09-06T14:22:50Z 2010-03-12 2013-09-06T14:22:50Z 2006-04-24 2010-03-12 2010-03-08 Dissertation Holo, L 2005, Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/23024 > E213/gm http://hdl.handle.net/2263/23024 http://upetd.up.ac.za/thesis/available/etd-03082010-172629/ © 2005, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Potentiometric membrane electrodes Enantiomers Chromatographic techniques UCTD Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title | Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title_full | Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title_fullStr | Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title_full_unstemmed | Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title_short | Enantioselective, potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| title_sort | enantioselective potentiometric membrane electrodes for enantioanalysis of amino acids of clinical and pharmaceutical importance |
| topic | Potentiometric membrane electrodes Enantiomers Chromatographic techniques UCTD |
| url | http://hdl.handle.net/2263/23024 http://upetd.up.ac.za/thesis/available/etd-03082010-172629/ |