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Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats
Dissertation (MMedVet (Med))--University of Pretoria, 2001.
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University of Pretoria
2013
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| _version_ | 1867613658759036928 |
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| access_status_str | Open Access |
| author2 | Lobetti, R.G. (Remo Giuseppe) |
| author_browse | Lobetti, R.G. (Remo Giuseppe) |
| author_facet | Lobetti, R.G. (Remo Giuseppe) |
| collection | Thesis |
| dc_rights_str_mv | © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet (Med))--University of Pretoria, 2001. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/23370 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:39.216Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/23370 Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats Lobetti, R.G. (Remo Giuseppe) upetd@ais.up.ac.za Schoeman, Johan P. No key words available UCTD Dissertation (MMedVet (Med))--University of Pretoria, 2001. Fifteen middle-aged to older, overweight cats were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotrophic hormone (ACTH) stimulation test. The cats received intravenous synthetic ACTH (tetracosactrin) at a dose of 125 µg initially and then, between 2 and 3 weeks later, a second test was performed using a dose of 250 µg intravenously. The peak of the mean serum cortisol concentrations taken at all time points, occurred at 60 minutes following the 125 µg dose and at 120 minutes following the 250 µg dose. There was no statistically significant difference between the cortisol peaks attained using either dose of tetracosactrin. There was, however, a significantly higher serum cortisol concentration attained after the higher dose at the 180 minutes time point, indicating a more prolonged response, when compared with the lower dose. The mean basal cortisol concentration was 203 nmol/l (range 81 – 354 nmol/l). The cats were followed up for one year after the initial investigations. Urine obtained one year later in the cats’ home environment, showed a mean urinary cortisol/creatinine ratio (UCCR) of 3.3 x 10 -6 (range 0.85 - 8.67 x 10 -6). A mean weight loss of 6 per cent was achieved over the period of the study. The weight loss, lack of development of clinical signs and the normal UCCR’s confirm that none of these cats had gone on to develop hyperadrenocorticism. Companion Animal Clinical Studies unrestricted 2013-09-06T15:11:31Z 2005-03-23 2013-09-06T15:11:31Z 2001-03-06 2006-03-23 2005-03-23 Dissertation Schoeman, J 2001, Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats, MMedVet dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/23370 > 7005814117 J-6765-2013 http://hdl.handle.net/2263/23370 http://upetd.up.ac.za/thesis/available/etd-03232005-132730/ © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | No key words available UCTD Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title | Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title_full | Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title_fullStr | Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title_full_unstemmed | Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title_short | Comparative response of blood cortisol levels to two different doses of intravenous acth (tetracosactrin) in overweight cats |
| title_sort | comparative response of blood cortisol levels to two different doses of intravenous acth tetracosactrin in overweight cats |
| topic | No key words available UCTD |
| url | http://hdl.handle.net/2263/23370 http://upetd.up.ac.za/thesis/available/etd-03232005-132730/ |