Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis
Dissertation (MMedVet (Med))--University of Pretoria, 2002.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Published: |
University of Pretoria
2013
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613679716925440 |
|---|---|
| access_status_str | Open Access |
| author2 | Jacobson, Linda S. |
| author_browse | Jacobson, Linda S. |
| author_facet | Jacobson, Linda S. |
| collection | Thesis |
| dc_rights_str_mv | © 2002, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet (Med))--University of Pretoria, 2002. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/23546 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:59.298Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/23546 Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis Jacobson, Linda S. Leisewitz, Andrew L. upetd@ais.up.ac.za Mohr, Albertus Jacobus No key words available UCTD Dissertation (MMedVet (Med))--University of Pretoria, 2002. Canine parvovirus (CPV) infection is characterized by a disruption of gut barrier function, which allows the systemic entry of bacteria and endotoxin, and the development of the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Despite the lack of prospective data, conventional wisdom has dictated that “gut rest” with initial nil per os (NPO) remains the nutritional treatment of choice for CPV enteritis. However, early enteral nutrition (EEN) has been shown to be superior to starvation in human critical illnesses associated with gut barrier dysfunction. Documented benefits of EEN include improved intestinal permeability, reduced incidences of bacteremia, endotoxemia, SIRS and MODS, decreased catabolism, and improved clinical outcome. A prospective, randomized, controlled clinical trial was conducted to evaluate the effect of EEN on intestinal permeability, protein-losing enteropathy, and clinical outcome in naturally occurring severe CPV enteritis in 30 puppies. Parvoviral infection was confirmed by fecal electron microscopy, and dogs were hospitalized for 6 days. Dogs were randomly assigned to 2 groups. Fifteen dogs received nil per os until vomiting had ceased for 12 hours, after which a low fat diet was fed (initial NPO group; control). Fifteen dogs were fed immediately (Pedigree® Canine Concentration Instant Diet) by nasoesophageal tube (EEN group). All other treatments were identical. Disease severity was semi-quantified by a clinical scoring system. Intestinal permeability was assessed using urinary lactulose and rhamnose recoveries (%L and %R) and L/R ratios. Fecal <FONT FACE=”SYMBOL”>a</FONT>1-proteinase inhibitor concentrations (<FONT FACE=”SYMBOL”>a</FONT>1-PI) quantified protein-losing enteropathy. Enteral tube feeding was not associated with any significant complications. The median time taken to normalization of habitus and appetite, and the resolution of vomiting and diarrhea, was consistently 1 day shorter for the EEN group for each parameter. Body weight remained stable in the NPO group, while EEN was associated with significant weight gain (8.4% by day 6). This supports reduced catabolism with EEN. Compared with reference values, urinary %Ls were elevated, %Rs reduced, and L/R ratios increased throughout the study for both groups. %L behaved significantly differently between groups (p=0.035), with a progressive decrease in the EEN group vs. a progressive increase in NPO. This may indicate earlier repair of intestinal epithelial necrosis, or improved tight junction structure and/or function due to EEN. Such an improvement in gut barrier function might potentially limit endotoxin and/or bacterial translocation. The decreased %R in both groups is consistent with villus atrophy. There were no significant differences in %R or L/R ratios between the two groups over time. Fecal <FONT FACE=”SYMBOL”>a</FONT>1-PI concentrations were increased throughout the study in both groups. There were no significant differences between the declines over time for fecal <FONT FACE=”SYMBOL”>a</FONT>1-PI concentrations between groups. Thirteen of 15 NPO dogs (87%) and all of the EEN dogs (100%) survived (non-significant; p = 0.48). This study demonstrates that EEN may be effectively instituted in CPV enteritis, and supports the use of EEN in gut barrier dysfunction. Companion Animal Clinical Studies unrestricted 2013-09-06T15:33:27Z 2005-03-29 2013-09-06T15:33:27Z 2002-10-06 2006-03-29 2005-03-29 Dissertation Mohr, A 2002, Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis, MMedVet dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/23546 > http://hdl.handle.net/2263/23546 http://upetd.up.ac.za/thesis/available/etd-03292005-103733/ © 2002, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | No key words available UCTD Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title | Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title_full | Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title_fullStr | Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title_full_unstemmed | Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title_short | Effect of early enteral nutrition on intestinal permeability, protein-losing enteropathy and outcome in canine parvoviral enteritis |
| title_sort | effect of early enteral nutrition on intestinal permeability protein losing enteropathy and outcome in canine parvoviral enteritis |
| topic | No key words available UCTD |
| url | http://hdl.handle.net/2263/23546 http://upetd.up.ac.za/thesis/available/etd-03292005-103733/ |