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An evaluation of the anti-allergic properties of potassium humate
Dissertation (MSc (Pharmacology))--University of Pretoria, 2008.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613469133504513 |
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| access_status_str | Open Access |
| author2 | Medlen, Connie E. |
| author_browse | Medlen, Connie E. |
| author_facet | Medlen, Connie E. |
| collection | Thesis |
| dc_rights_str_mv | © University of Pretoria 2007 E792 |
| description | Dissertation (MSc (Pharmacology))--University of Pretoria, 2008. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/24209 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:36:38.421Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/24209 An evaluation of the anti-allergic properties of potassium humate Medlen, Connie E. jjgandy@webmail.co.za Gandy, Justin John Neutrophils Inflammation Humic acid Eosinophils Allergic rhinitis Cytokines Basophils UCTD Dissertation (MSc (Pharmacology))--University of Pretoria, 2008. The objective was to establish the safety and therapeutic efficacy of oral potassium humate in reducing the signs and symptoms of hayfever. Potassium humate was randomly assigned to 40 atopic patients with acute symptoms of hayfever. Blood and nasal samples were used to determine the safety and the effects of potassium humate on basophil activation, cytokine levels and eosinophil migration. A skin prick test was used to determine its anti-allergic effects. An in vitro neutrophil adhesion was also used. A significant decrease in the skin prick test results and eosinophil counts was observed. No significant differences were observed with regard to neutrophil adhesion nor were any differences observed with regard to the stimulation of basophils. Decreases were observed in the expression of IL-4, IL-5, IL-8 and IL-1â after treatment, although not reaching significance. This study confirmed that this product possesses anti-inflammatory and anti-allergic properties possibly due to a decreased recruitment of eosinopils to the inflammatory site the recruitment and activation of eosinophils by decreasing the expression of IL-4, IL-5, IL-8 and IL-1â, although not reaching statistical significance. Pharmacology unrestricted 2013-09-06T16:56:05Z 2008-07-11 2013-09-06T16:56:05Z 2007-09-07 2008-07-11 2008-04-29 Dissertation a 2007 E792 AG http://hdl.handle.net/2263/24209 http://upetd.up.ac.za/thesis/available/etd-04292008-095801/ © University of Pretoria 2007 E792 application/pdf University of Pretoria |
| spellingShingle | Neutrophils Inflammation Humic acid Eosinophils Allergic rhinitis Cytokines Basophils UCTD An evaluation of the anti-allergic properties of potassium humate |
| title | An evaluation of the anti-allergic properties of potassium humate |
| title_full | An evaluation of the anti-allergic properties of potassium humate |
| title_fullStr | An evaluation of the anti-allergic properties of potassium humate |
| title_full_unstemmed | An evaluation of the anti-allergic properties of potassium humate |
| title_short | An evaluation of the anti-allergic properties of potassium humate |
| title_sort | evaluation of the anti allergic properties of potassium humate |
| topic | Neutrophils Inflammation Humic acid Eosinophils Allergic rhinitis Cytokines Basophils UCTD |
| url | http://hdl.handle.net/2263/24209 http://upetd.up.ac.za/thesis/available/etd-04292008-095801/ |