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Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment
Dissertation (MSc (Chemistry))--University of Pretoria, 2008.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613493464662016 |
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| access_status_str | Open Access |
| author2 | Cukrowski, Ignacy |
| author_browse | Cukrowski, Ignacy |
| author_facet | Cukrowski, Ignacy |
| collection | Thesis |
| dc_rights_str_mv | © University of Pretoria 2007E989/ |
| description | Dissertation (MSc (Chemistry))--University of Pretoria, 2008. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/25441 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:37:01.683Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/25441 Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment Cukrowski, Ignacy castbrea@yahoo.com.br Castelo Branco, Jose Soares Bisphosphonates Bone cancer Cancer treatment UCTD Dissertation (MSc (Chemistry))--University of Pretoria, 2008. The nitrogen-containing bisphosphonates (N-BPs), 4-amino-1-hydroxy-1,1-butylidenebisphosphonic acid, or Alendronate, (ALN) and 6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid, or Neridronate (NED), were studied with metal ions Mg(II), Ca(II), Cd(II) and Pb(II) at ionic strength 0.15 M at 25 oC in NaCl. The complexes of ALN and NED with Mg(II) and Ca(II) were studied by glass electrode potentiometry (GEP), and with Cd(II) and Pb(II) by sampled direct current polarography (DCP) and normal pulse polarography (NPP) at fixed total ligand to total metal concentration ratios and varied pH values. Virtual potential was used in the modelling of the metal ligand-system derived from DCP and NPP. Protonation constants and complex formation constants for ligands ALN and NED with metal ions are reported. The structures of metal-complexes proposed were compared to the reported crystal structures of the metal-complexes of the ligands ALN and NED. The linear free energy relationships (LFER) that include stability constants log KML for Mg(II), Ca(II) and Cd(II) with ligands ALN and NED were used to estimate log KML values for Sm(III) and Ho(III) with ALN and NED. The stability constants estimated here might be regarded as not reliable due to the few points available for that purpose. Chemistry unrestricted 2013-09-06T21:33:16Z 2008-08-20 2013-09-06T21:33:16Z 2008-04-23 2008-08-20 2008-06-11 Dissertation a 2007E989/gm http://hdl.handle.net/2263/25441 http://upetd.up.ac.za/thesis/available/etd-06112008-125049/ © University of Pretoria 2007E989/ application/pdf University of Pretoria |
| spellingShingle | Bisphosphonates Bone cancer Cancer treatment UCTD Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title | Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title_full | Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title_fullStr | Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title_full_unstemmed | Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title_short | Complexing ability and activity of N-containing bisphosphonates in bone cancer treatment |
| title_sort | complexing ability and activity of n containing bisphosphonates in bone cancer treatment |
| topic | Bisphosphonates Bone cancer Cancer treatment UCTD |
| url | http://hdl.handle.net/2263/25441 http://upetd.up.ac.za/thesis/available/etd-06112008-125049/ |