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The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery
Dissertation (MChD (Chir Max-Fac Med))--University of Pretoria, 2007.
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University of Pretoria
2013
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| _version_ | 1867613516186255360 |
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| access_status_str | Open Access |
| author2 | Butow, Kurt-Wilhelm |
| author_browse | Butow, Kurt-Wilhelm |
| author_facet | Butow, Kurt-Wilhelm |
| collection | Thesis |
| dc_rights_str_mv | © 2000 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MChD (Chir Max-Fac Med))--University of Pretoria, 2007. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/25879 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:37:23.306Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/25879 The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery Butow, Kurt-Wilhelm upetd@up.ac.za Van Eeden, Simon Peter Oral medicine Mouth surgery Dentistry operative Antibiotics physiological effect Anti-inflammatory agents UCTD Dissertation (MChD (Chir Max-Fac Med))--University of Pretoria, 2007. Third molar surgery may be associated with a number of complications the most common of which are postoperative pain, swelling and trismus, and dry socket formation. The appearance of these post-operative sequelae is intimately related to the manifestations of inflammation in response to tissue injury. There is significant post-operative morbidity associated with these complications and it was thus the objective of this study to - investigate the effect of a combined antibiotic/anti-inflammatory intrasocket medication on post-operative pain, swelling and dry socket formation. The medication chosen for the study was Covomycin D®. Covomycin D® is a commercially prepared opthalmological preparation - each 1 millilitre contains 2 mg chloramphenicol, 5 mg neomycin sulphate and 0,5 mg dexamethasone. Nineteen subjects were included in the study after fullfilling certain criteria. All subjects were operated under general anaesthesia by the same surgeon. The patients were blinded to the side of the medication and were asked to complete a pain visual analogue scale and note the side of the worst swelling in the post¬operative period. All patients were followed up in the first week following surgery by an independent oral and maxillofacial surgeon who was also blinded to the side on which the medication was placed. The results showed a significant difference (p<0.6) in the pain experienced on the non-medicated compared to the medicated side on day one in eleven of the nineteen patients (57.9%). When the data was analysed over the six day postoperative period sixteen of the nineteen patients (84.2%) had significantly less pain on the medicated side compared to the non-medicated side (p<0.6). The swelling was reported as being worse on the non-medicated side in fourteen out of the nineteen patients (73.7%). Dry socket occurred in three out of nineteen patients or three out of thirty eight surgical extraction sites; an overall incidence of 7.9% or an incidence of 0% for the medicated side and an incidence of 15.8% on the non-medicated side i.e. all the dry sockets occurred on the non-medicated side. In conclusion, this double-blinded prospectve study, showed that the use of a combined antibiotic/anti-inflammatory intrasocket medication favourably influences the common adverse post-operative sequelae following the removal of lower third molars. Maxillo-Facial and Oral Surgery unrestricted 2013-09-07T01:06:39Z 2007-01-05 2013-09-07T01:06:39Z 2000-05-01 2007-01-05 2007-01-05 Dissertation Van Eeden, SP 2000, The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery, MChD dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/25879 > H807/ag http://hdl.handle.net/2263/25879 http://upetd.up.ac.za/thesis/available/etd-01052007-123151/ © 2000 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Oral medicine Mouth surgery Dentistry operative Antibiotics physiological effect Anti-inflammatory agents UCTD The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title | The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title_full | The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title_fullStr | The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title_full_unstemmed | The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title_short | The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery |
| title_sort | effect of a topical combined anti inflammatory antibiotic preparation on the outcome of third molar surgery |
| topic | Oral medicine Mouth surgery Dentistry operative Antibiotics physiological effect Anti-inflammatory agents UCTD |
| url | http://hdl.handle.net/2263/25879 http://upetd.up.ac.za/thesis/available/etd-01052007-123151/ |