Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The traditional use of medicinal plants to treat sexually transmitted diseases
Dissertation (MSc ( Plant Physiology))--University of Pretoria, 2006.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Published: |
University of Pretoria
2013
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613513955934209 |
|---|---|
| access_status_str | Open Access |
| author2 | Meyer, J.J.M. (Jacobus Johannes Marion) |
| author_browse | Meyer, J.J.M. (Jacobus Johannes Marion) |
| author_facet | Meyer, J.J.M. (Jacobus Johannes Marion) |
| collection | Thesis |
| dc_rights_str_mv | © 2002 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc ( Plant Physiology))--University of Pretoria, 2006. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/25889 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:37:20.986Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/25889 The traditional use of medicinal plants to treat sexually transmitted diseases Meyer, J.J.M. (Jacobus Johannes Marion) upetd@up.ac.za Tshikalange, Thilivhali Emmanuel Materia medica vegetable south africa Traditional medicine south africa Sexually transmitted diseases treatment Medicinal plants south africa UCTD Dissertation (MSc ( Plant Physiology))--University of Pretoria, 2006. All six plants studied (Senna petersiana, Terminalia sericea, Cassine transvaalensis, Elephantorrhiza burkei, Rauvolfia caffra and Anredera cordifolia) proved to have considerable antibacterial activity. The water extracts of five of the six plants tested, showed activity against Bacillus pumilis, B. subtilis and Staphylococcus aureus respectively. Water extracts from S. petersiana showed a significant antibacterial activity by inhibiting all Gram-positive and two Gram-negative bacteria. A cytotoxicity assay of three plants (S. petersiana, T. sericea and A. cordifolia) on primary vervet monkey kidney ceelsl showed that A. cordifolia was the least cytotoxic extract with an ID50 value of 1.560 mg/ml. Both S. petersian and T. sericea showed an ID50 value of 0.024 mg/ml. Cytotoxicity as determined in this study does not necessarily mean that the active compound which can be isolated from these plants will also be toxic. Antiviral activity of S. petersiana, T. sericea and A. cordifoli crude extracts were investigated against herpes simplex virus type I at the non-toxic concentrations. Both T. sericea and A. cordifoli extracts showed to be non-active against HSV -I, but S. petersiana showed a 20 % reduction in replication of the virus after the sixth day of the experiment. Because of the sensitivity and instability of compounds in the root extract of S. petersiana, it was very difficult to isolate any pure compound. Bioassay-guided fractionation of the seeds of S. petersiana resulted in the isolation luteolin. Its structure was identified and confirmed through spectroscopic methods including IH, BC, UV, HMBC and HMBQ. An antibacterial assay of luteolin isolated from the seeds of S. petersiana showed activity against Baccilus cereus, B. pumilis, Streptococcus aureus and Staphylococcus areus at the concentration of I mg/ml. In the assay to assess the possible antiviral activity of luteolin against herpes simplex type I virus, 50% of the virus was inactivated at the concentration of 250 μg/ml. The results of this study have shown that it is possibl4e that the extracts studied, can provide humankind with valuable agents of potential use in the treatment of herpes and some bacterial species. Plant Science unrestricted 2013-09-07T01:10:49Z 2005-07-05 2013-09-07T01:10:49Z 2003-04-03 2006-07-05 2005-06-27 Dissertation Botha, CP 2002, Simulation of a building heating, ventilating and air-conditioning system, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/25889 > H820/ag http://hdl.handle.net/2263/25889 http://upetd.up.ac.za/thesis/available/etd-06272005-130928/ © 2002 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Materia medica vegetable south africa Traditional medicine south africa Sexually transmitted diseases treatment Medicinal plants south africa UCTD The traditional use of medicinal plants to treat sexually transmitted diseases |
| title | The traditional use of medicinal plants to treat sexually transmitted diseases |
| title_full | The traditional use of medicinal plants to treat sexually transmitted diseases |
| title_fullStr | The traditional use of medicinal plants to treat sexually transmitted diseases |
| title_full_unstemmed | The traditional use of medicinal plants to treat sexually transmitted diseases |
| title_short | The traditional use of medicinal plants to treat sexually transmitted diseases |
| title_sort | traditional use of medicinal plants to treat sexually transmitted diseases |
| topic | Materia medica vegetable south africa Traditional medicine south africa Sexually transmitted diseases treatment Medicinal plants south africa UCTD |
| url | http://hdl.handle.net/2263/25889 http://upetd.up.ac.za/thesis/available/etd-06272005-130928/ |