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A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning
Dissertation (MSc (Paraclinical Sciences))--University of Pretoria, 2005.
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University of Pretoria
2013
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| _version_ | 1867613683727728640 |
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| access_status_str | Open Access |
| author2 | Naidoo, Vinny |
| author_browse | Naidoo, Vinny |
| author_facet | Naidoo, Vinny |
| collection | Thesis |
| dc_rights_str_mv | © 2004, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Paraclinical Sciences))--University of Pretoria, 2005. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/25890 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:40:02.981Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/25890 A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning Naidoo, Vinny Botha, C.J. (Christoffel Jacobus) upetd@ais.up.ac.za Verster, Ryno Stockenström Hydroxypropyl Survey Questionnaire Rats Poisoning Aldicarb Cats Gauteng Dogs Treatment UCTD Dissertation (MSc (Paraclinical Sciences))--University of Pretoria, 2005. Worldwide, pesticides are applied to protect crops against insects, fungi and other parasites. Without these chemicals it would not be possible to produce sufficient food to satisfy the demand of an ever-increasing world population. Unfortunately, many cases of accidental and intentional poisoning of humans and animals occur and the objectives of this study were to obtain statistics of aldicarb poisoning in companion animals in Gauteng Province and to evaluate hydroxypropyl-<font face="symbol">b</font>-cyclodextrin as a potential treatment. Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Aldicarb is moderately lipid-soluble, non-ionized and of low molecular weight and thus fits all criteria for complexation with cyclodextrin. Questionnaires were posted to all private practitioners in Gauteng. The survey was designed to determine the percentage of aldicarb cases seen, clinical signs observed, treatment regimen, proposals for preventative actions and more effective treatments. Other questions included duration of treatment, survival rate, cost to client, post-mortem findings and reasons for poisonings. Thirty-four percent of respondants indicated the total number of all clinical cases presented at their practices during 2003. The percentage of suspected aldicarb cases as a proportion of all cases ranged from 0.05 - 2.6 % for dogs and 0.09 - 3.33 % for cats. Only 26.5 % of practitioners sometimes submitted samples for laboratory confirmation of aldicarb poisoning. Salivation and tremors were the most common clinical signs observed by private practitioners and the majority of suspected poisoning cases were treated with atropine, intravenous fluid and electrolyte therapy and the oral administration of activated charcoal. Thirty-three respondents thought that there was an increase in the number of aldicarb cases, but 35 felt there was no increase during 2003. Fifteen respondents were reluctant to venture an opinion. Most veterinarians indicated that criminal intent was the main reason why animals were poisoned and 95 % of respondents reported that it occurred throughout the year, but an increased incidence was observed during holiday periods.Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer, compared to the control rats only dosed with aldicarb per os. Rats receiving cyclodextrin immediately before aldicarb, survived longer when compared to rats, which received aldicarb prior to cyclodextrin. Paraclinical Sciences unrestricted 2013-09-07T01:10:51Z 2005-06-27 2013-09-07T01:10:51Z 2004-02-17 2006-06-27 2005-06-27 Dissertation Verster, R 2004, A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/25890 > http://hdl.handle.net/2263/25890 http://upetd.up.ac.za/thesis/available/etd-06272005-152446/ © 2004, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Hydroxypropyl Survey Questionnaire Rats Poisoning Aldicarb Cats Gauteng Dogs Treatment UCTD A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title | A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title_full | A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title_fullStr | A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title_full_unstemmed | A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title_short | A survey of aldicarb poisoning in dogs and cats in Gauteng and evaluation of the efficacy of hydroxypropyl-β-cyclodextrin as a treatment in aldicarb poisoning |
| title_sort | survey of aldicarb poisoning in dogs and cats in gauteng and evaluation of the efficacy of hydroxypropyl β cyclodextrin as a treatment in aldicarb poisoning |
| topic | Hydroxypropyl Survey Questionnaire Rats Poisoning Aldicarb Cats Gauteng Dogs Treatment UCTD |
| url | http://hdl.handle.net/2263/25890 http://upetd.up.ac.za/thesis/available/etd-06272005-152446/ |