Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Isolation and identification of poisonous triterpenoids from Elaeodendron croceum
Dissertation (MSc)--University of Pretoria, 2010.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Published: |
University of Pretoria
2013
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613664861749248 |
|---|---|
| access_status_str | Open Access |
| author2 | Meyer, J.J.M. (Jacobus Johannes Marion) |
| author_browse | Meyer, J.J.M. (Jacobus Johannes Marion) |
| author_facet | Meyer, J.J.M. (Jacobus Johannes Marion) |
| collection | Thesis |
| dc_rights_str_mv | © 2009, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2010. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/27938 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:45.040Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/27938 Isolation and identification of poisonous triterpenoids from Elaeodendron croceum Meyer, J.J.M. (Jacobus Johannes Marion) s24443027@tuks.co.za Yelani, Thembela Cytotoxicity Elaeodendron croceum Triterpenes UCTD Dissertation (MSc)--University of Pretoria, 2010. Various plant species have been reported traditionally as well as in scientific literature for cytotoxicity against animal species. Isolation of several poisonous compounds from plant species has been reported previously. Elaeodendron croceum is a well-known poisonous plant species of which the poisonous compounds have not yet been isolated. A phytochemical investigation of E. croceum leaves guided by cytotoxicity against Vero cells, led to the isolation of five known compounds; 20-hydroxy-20-epi-tingenone (1), tingenone (2), tingenine B (3), 11α-hydroxy-β-amyrin (4), and naringenin (5). Compounds 1 and 2 showed the highest toxicity against Vero cells (IC50: 2.651 nM and 8.233 μM respectively). Cytotoxicity of the isolated compounds against three human cancer cell lines, HeLa, MCF-7, and SNO was also determined. Compounds 1 and 2 again showed the highest cytotoxicity with IC50 values ranging between 2.478 – 0.427 μM. This is the first report on the isolation, identification, and in vitro evaluation of poisonous compounds from E. croceum. Copyright Plant Production and Soil Science unrestricted 2013-09-07T12:38:28Z 2010-09-14 2013-09-07T12:38:28Z 2010-04-28 2010-09-14 2010-09-14 Dissertation Yelani, T 2009, Isolation and identification of poisonous triterpenoids from Elaeodendron croceum, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/27938 > E10/395/gm http://hdl.handle.net/2263/27938 http://upetd.up.ac.za/thesis/available/etd-09142010-200331/ © 2009, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Cytotoxicity Elaeodendron croceum Triterpenes UCTD Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title | Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title_full | Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title_fullStr | Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title_full_unstemmed | Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title_short | Isolation and identification of poisonous triterpenoids from Elaeodendron croceum |
| title_sort | isolation and identification of poisonous triterpenoids from elaeodendron croceum |
| topic | Cytotoxicity Elaeodendron croceum Triterpenes UCTD |
| url | http://hdl.handle.net/2263/27938 http://upetd.up.ac.za/thesis/available/etd-09142010-200331/ |