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Modelled response of the electrically stimulated human auditory nerve fibre
Thesis (PhD)--University of Pretoria, 2010.
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University of Pretoria
2013
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| _version_ | 1867613503955664896 |
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| access_status_str | Open Access |
| author2 | Hanekom, Tania |
| author_browse | Hanekom, Tania |
| author_facet | Hanekom, Tania |
| collection | Thesis |
| dc_rights_str_mv | © 2008 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2010. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/28014 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:37:11.641Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/28014 Modelled response of the electrically stimulated human auditory nerve fibre Hanekom, Tania Hanekom, J.J. (Johannes Jurgens) kobie.smit@up.ac.za Smit, Jacoba Elizabeth Evoked compound action potential Computational model Human Auditory nerve fibre Generalised sensory nerve fibre Hodgkin-huxley model Temporal characteristics Strength-duration time constant Ionic membrane currents Conduction velocity UCTD Thesis (PhD)--University of Pretoria, 2010. This study determined whether the Hodgkin-Huxley model for unmyelinated nerve fibres could be more comprehensively modified to predict excitation behaviour at Ranvier nodes of a human sensory nerve fibre, as specifically applied to the prediction of temporal characteristics of the human auditory system. The model was developed in three phases. Firstly, the Hodgkin-Huxley model was modified to describe action potential dynamics at Ranvier nodes using recorded ionic membrane current data from single human myelinated peripheral nerve fibres. A nerve fibre cable model, based on a combination of two existing models, was subsequently developed using human sensory nerve fibre morphometric data. Lastly the morphological parameters of the nerve fibre model were changed to resemble a Type I peripheral auditory nerve fibre and coupled to a volume-conduction model of the cochlea. This study is the first to show that the Hodgkin-Huxley model equations can be modified successfully to predict excitation behaviour of a generalised human peripheral sensory nerve fibre without using the Goldman-Hodgkin-Katz equations. The model includes a more comprehensive establishment of temperature dependence of the physiological and electrical parameters compared to existing models. Two versions of the human Type I auditory nerve fibre model were developed, one simulating an undamaged (non-degenerate) fibre and another a damaged (degenerate) fibre. Comparison between predicted and measured results indicated similar transient and persistent sodium, as well as slow potassium ionic membrane currents to those found in generalised sensory nerve fibres. Results confirm that chronaxie, rheobase current, mean latency, threshold and relative refractive periods depend on the amount of degeneracy of fibres. The model could account for threshold differences observed between different asymmetric waveforms. The combination of persistent sodium and slow potassium ionic membrane currents could in part predict non-monotonic excitation behaviour observed experimentally. A simplified method was developed to calculate electrically evoked compound action potential responses following neural excitation. It provided a computationally effective way to obtain an estimate of profile widths from the output of models that calculate neural excitation profiles, and an indirect way to estimate stimulus attenuation by calculating the value of the parameter that produces the best fit to experimental data. Results also confirmed that electrode arrays located closer to the modiolus produce more focussed neural excitation spread than more laterally located arrays. Electrical, Electronic and Computer Engineering unrestricted 2013-09-07T12:43:32Z 2008-10-01 2013-09-07T12:43:32Z 2008-09-02 2010-10-02 2008-09-18 Thesis Smit, JE 2008, Modelled response of the electrically stimulated human auditory nerve fibre, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/28014 > B25/ag http://hdl.handle.net/2263/28014 http://upetd.up.ac.za/thesis/available/etd-09182008-144232/ © 2008 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf University of Pretoria |
| spellingShingle | Evoked compound action potential Computational model Human Auditory nerve fibre Generalised sensory nerve fibre Hodgkin-huxley model Temporal characteristics Strength-duration time constant Ionic membrane currents Conduction velocity UCTD Modelled response of the electrically stimulated human auditory nerve fibre |
| title | Modelled response of the electrically stimulated human auditory nerve fibre |
| title_full | Modelled response of the electrically stimulated human auditory nerve fibre |
| title_fullStr | Modelled response of the electrically stimulated human auditory nerve fibre |
| title_full_unstemmed | Modelled response of the electrically stimulated human auditory nerve fibre |
| title_short | Modelled response of the electrically stimulated human auditory nerve fibre |
| title_sort | modelled response of the electrically stimulated human auditory nerve fibre |
| topic | Evoked compound action potential Computational model Human Auditory nerve fibre Generalised sensory nerve fibre Hodgkin-huxley model Temporal characteristics Strength-duration time constant Ionic membrane currents Conduction velocity UCTD |
| url | http://hdl.handle.net/2263/28014 http://upetd.up.ac.za/thesis/available/etd-09182008-144232/ |