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Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease
Dissertation (MMed Vet (Med))--University of Pretoria, 2001.
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University of Pretoria
2013
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| _version_ | 1867613617095966720 |
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| access_status_str | Open Access |
| author2 | Jacobson, Linda S. |
| author_browse | Jacobson, Linda S. |
| author_facet | Jacobson, Linda S. |
| collection | Thesis |
| dc_rights_str_mv | © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria |
| description | Dissertation (MMed Vet (Med))--University of Pretoria, 2001. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/29287 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:38:59.552Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/29287 Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease Jacobson, Linda S. upetd@up.ac.za Reyers, Fred Vaughan-Scott, Tarquin Babesia canis Dogs -- Diseases Necrosis Tumor necrosis factor UCTD Dissertation (MMed Vet (Med))--University of Pretoria, 2001. Please read the abstract in the section 00front of this document Canine babesiosis, caused by the tick-borne protozoan Babesia canis rossi, is an economically important and potentially fatal disease of dogs in South Africa. The host's response to many infectious diseases is mediated (at least in part) by intercellular messengers called cytokines. One of the most important cytokines released is tumour necrosis factor (TNF). A study was designed to measure serum concentrations of TNF in dogs naturally infected with canine babesiosis and to relate TNF concentrations to clinical severity, mortality, rectal temperature and parasitaemia. There was a statistically significant difference in TNF concentrations between groups of differing disease severity, with a general trend of increasing mean 10g(TNF) with increasing severity of disease. A noteworthy finding was that dogs with hypoglycaemia had very high TNF (mean 15.03 nglml compared to a mean of 2.32 nglml for other sick dogs without hypoglycaemia). When TNF values were compared between survival and non-survival groups, there was no significant difference. The rectal temperature of the dogs in this study did not show any statistically significant association with TNF concentrations. When parasitaemia and TNF were examined within groups of infected dogs, there was no significant relationship. However, when the sample size was increased by pooling all infected dogs and treating them as a single group, there was a highly significant positive correlation (p = 0.003) between parasitaemia and serum TNF concentrations. The results ofthis study were encouraging and indicate that canine babesiosis may share a similar pathophysiology with human malaria in terms ofTNF being associated with disease severity. One ofthe most significant findings in this study was the presence ofvery high TNF values in two ofthree dogs with hypoglycaemia. Hypoglycaemia has not been previously recorded in dogs with babesiosis and is a potentially important finding particularly in view ofthe hypoglycaemia associated with malaria in humans. Malarial hypoglycaemia is correlated with a higher mortality in humans, especially in pregnant women and children. If the findings ofthis study can be Vl confinned and expanded, they may lend further support to the use of canine babesiosis as a model for some ofthe problems encountered in human malaria research. Companion Animal Clinical Studies unrestricted 2013-09-07T15:17:17Z 2005-11-14 2013-09-07T15:17:17Z 2002-04-01 2006-11-14 2005-11-07 Dissertation Vaughan-Scott T, 2001, Serum concentrations of tumor necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease, M Med Vet dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/29287 > H267/th http://hdl.handle.net/2263/29287 http://upetd.up.ac.za/thesis/available/etd-11072005-164426/ © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria application/pdf application/pdf application/pdf University of Pretoria |
| spellingShingle | Babesia canis Dogs -- Diseases Necrosis Tumor necrosis factor UCTD Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title | Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title_full | Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title_fullStr | Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title_full_unstemmed | Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title_short | Serum concentrations of tumour necrosis factor in dogs naturally infected with Babesia Canis and its relation to severity of disease |
| title_sort | serum concentrations of tumour necrosis factor in dogs naturally infected with babesia canis and its relation to severity of disease |
| topic | Babesia canis Dogs -- Diseases Necrosis Tumor necrosis factor UCTD |
| url | http://hdl.handle.net/2263/29287 http://upetd.up.ac.za/thesis/available/etd-11072005-164426/ |