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Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers
Dissertation (MMed Vet (Pathology))--University of Pretoria, 1999.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613443017670656 |
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| access_status_str | Open Access |
| author2 | Nesbit, J.W. |
| author_browse | Nesbit, J.W. |
| author_facet | Nesbit, J.W. |
| collection | Thesis |
| dc_rights_str_mv | © 1999, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria |
| description | Dissertation (MMed Vet (Pathology))--University of Pretoria, 1999. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/29493 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:36:13.446Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/29493 Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers Nesbit, J.W. Pearson, Joyce Lymphocytes classification Immunophenotyping Lymphomas Dogs UCTD Dissertation (MMed Vet (Pathology))--University of Pretoria, 1999. Inconsistent use of nomenclature in different canine malignant lymphoma (CML)classification systems, which lead to incorrect diagnosis and prognosis, necessitated a retrospective study of 103 cases of CML. Histological classification was done according to the Working Formulation, on H&E sections, after standard processing. Immunophenotyping, using CD3 (T cell) and CD79a (8cell) markers, was carried out on the same sections. Intermediate grade lymphomas were the largest category (49.5%), with 16.5%high grade lymphomas. More than half (53.3%) of the lymphomas were of 8 cell immuno phenotype, and 36.5% were T cell lymphomas. Only 9.7% of the total number of lymphomas exhibited double negative staining. Only two categories, the immunoblastic and medium-sized macro nucleolated (MMC) category (Fournel-Fleury et al.). exhibited constant (8 cell) immunophenotype. All the other categories exhibited mixed immunophenotype. The Working Formulation, with omission of the follicular tyoes (due to the rarity thereof in CML) and addition of the MMC category and immunophenotyping, is best for classifying CML. Anatomy and Physiology Unrestricted 2013-09-07T15:45:51Z 2006-11-16 2013-09-07T15:45:51Z 1999-04-01 2007-11-16 2006-11-16 Dissertation Pearson J, 1999, Immunophenotypic classificatopn of canine malignant lymphoma in formalin-fixed paraffin wax-embedded specimens using CD3 and CD79a cell markers, M Med Vet dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/29493 > H266/th http://hdl.handle.net/2263/29493 http://upetd.up.ac.za/thesis/available/etd-11162006-121839/ © 1999, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria application/pdf University of Pretoria |
| spellingShingle | Lymphocytes classification Immunophenotyping Lymphomas Dogs UCTD Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title | Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title_full | Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title_fullStr | Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title_full_unstemmed | Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title_short | Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers |
| title_sort | immunophenotypic classification of canine malignant lymphoma in formalin fixed paraffin wax embedded specimens using cd3 and cd79a cell markers |
| topic | Lymphocytes classification Immunophenotyping Lymphomas Dogs UCTD |
| url | http://hdl.handle.net/2263/29493 http://upetd.up.ac.za/thesis/available/etd-11162006-121839/ |