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The Synthesis and analysis of methaqualone and some positional structural isomers thereof
Dissertation (MSc Applied Sciences (Chemistry))--University of Pretoria, 2006.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613621936193536 |
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| access_status_str | Open Access |
| author2 | Modro, T.A. |
| author_browse | Modro, T.A. |
| author_facet | Modro, T.A. |
| collection | Thesis |
| dc_rights_str_mv | © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc Applied Sciences (Chemistry))--University of Pretoria, 2006. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/29713 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:04.068Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/29713 The Synthesis and analysis of methaqualone and some positional structural isomers thereof Modro, T.A. upetd@up.ac.za Van Zyl, Etienne Francois Methaqualone synthesis Methaqualone analysis UCTD Dissertation (MSc Applied Sciences (Chemistry))--University of Pretoria, 2006. An extensive review of the reported synthesis of methaqualone (2-methyl-3-ο-tolyl-4(3H)-quinazolinone) and some positional and structural isomers of methaqualone is given. A detailed summary of the synthetic routes reviewed is given as an appendix. Methaqualone, four previously reported, and seven until hereto unreported isomers of methaqualone were prepared using a modified, known synthetic route for quinazolinones. The modified route allowed for the rapid laboratory scale preparation of the desired quinazolinones in high yields. Melting points are given. The prepared compounds were characterized using various organic analytical techniques. NMR and IR was found to be the most specific single techniques for the effectively and unequivocally differentiation between the studied compounds. The most convenient, and equally specific, differentiation was achieved using coupled gas-liquid chromatography. The thin-layer chromatography and liquid chromatography systems evaluated proved of no value in differentiating the thirteen isomers. Chemistry unrestricted 2013-09-07T16:19:56Z 2005-11-30 2013-09-07T16:19:56Z 2002-04-01 2006-11-30 2005-11-23 Dissertation Van Zyl, EF 2001, The synthesis and analysis of methaqualone and some positional and structural isomers thereof, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/29713 > H725/ag http://hdl.handle.net/2263/29713 http://upetd.up.ac.za/thesis/available/etd-11232005-150329/ © 2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Methaqualone synthesis Methaqualone analysis UCTD The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title | The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title_full | The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title_fullStr | The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title_full_unstemmed | The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title_short | The Synthesis and analysis of methaqualone and some positional structural isomers thereof |
| title_sort | synthesis and analysis of methaqualone and some positional structural isomers thereof |
| topic | Methaqualone synthesis Methaqualone analysis UCTD |
| url | http://hdl.handle.net/2263/29713 http://upetd.up.ac.za/thesis/available/etd-11232005-150329/ |