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Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis)
Dissertation (MSc (Zoology))--University of Pretoria, 2006.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613615426633728 |
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| access_status_str | Open Access |
| author2 | Van Aarde, Rudi J. |
| author_browse | Van Aarde, Rudi J. |
| author_facet | Van Aarde, Rudi J. |
| collection | Thesis |
| dc_rights_str_mv | © 1999 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Zoology))--University of Pretoria, 2006. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/30149 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:38:57.791Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/30149 Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) Van Aarde, Rudi J. upetd@up.ac.za Wallace, Esme Denise Hyraxes UCTD Dissertation (MSc (Zoology))--University of Pretoria, 2006. The mean dissociation constant (± SEM) of the uterine progesterone receptor for progesterone in eight rock hyraxes, culled at Elandsrand Mine Reserve, was 1.78 nM (±O.l07). The receptor also showed a high relative binding affinity (RBA) for the synthetic hormones norethindrone (%RBA = 185), levonorgestrel (%RBA = 179) and RU486 (%RBA = 221). The binding of norethindrone is similar to that of the African elephant and thus allows for the use of the hyrax as a biological model for the development of a contraceptive for the elephant as an alternative to elephant culling. Norethindrone and cholesterol (placebo) implants in 18 captive hyraxes resulted in zero pregnancies for the seven animals receiving norethindrone, five pregnancies in the eight animals receiving cholesterol and three pregnancies in the three animals receiving no implants. Circulating oestradiol-17Â and progesterone concentrations of the mid-pregnant and non-pregnant animals were similar to those in free ranging hyraxes, suggesting that norethindrone had no effect on the availability of these hormones. Histological investigation of selected organs (adrenals, liver, spleen, uterus and ovaries) showed that the effects of norethindrone were limited to the endometrial and ovarian tissue. The endometrium showed atrophic glands and proliferating stromal cells while the ovaries were inactivated. This indicated that norethindrone possibly interferes with both the uterine environment and ovulation, thus preventing conception. This study indicates that norethindrone has contraceptive abilities in the rock hyrax that can potentially be extrapolated to the African elephant, in the search for a contraceptive to manage high population growth rates. Zoology and Entomology unrestricted 2013-09-07T18:06:49Z 2006-12-06 2013-09-07T18:06:49Z 1999-12-01 2006-12-06 2006-12-06 Dissertation Wallace, ED 1999, Some characteristics of the uterine progesterone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis), MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/30149 > H837/ag http://hdl.handle.net/2263/30149 http://upetd.up.ac.za/thesis/available/etd-12062006-132534/ © 1999 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Hyraxes UCTD Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title | Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title_full | Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title_fullStr | Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title_full_unstemmed | Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title_short | Some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax (Procavia capensis) |
| title_sort | some characteristics of the uterine progestorone receptor and the effects of norethindrone on conception in the rock hyrax procavia capensis |
| topic | Hyraxes UCTD |
| url | http://hdl.handle.net/2263/30149 http://upetd.up.ac.za/thesis/available/etd-12062006-132534/ |