Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy
Thesis (PhD)--University of Pretoria, 2006.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Published: |
University of Pretoria
2013
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613547164336128 |
|---|---|
| access_status_str | Open Access |
| author2 | Xia, Xiaohua |
| author_browse | Xia, Xiaohua |
| author_facet | Xia, Xiaohua |
| collection | Thesis |
| dc_rights_str_mv | © 2006, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2006. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/30379 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:37:52.763Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/30379 A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy Xia, Xiaohua jeffreym@mopipi.ub.bw Craig, Ian K. Jeffrey, Annah Mandu Hiv/aids models HIV immunology Initiate HIV therapy HIV/AIDS model analysis Biomedical engineering Model predictive control Control engineering in medicine Immune based therapy Protocol design Structured treatment interruption Drug dosage design UCTD Thesis (PhD)--University of Pretoria, 2006. Current research on HIV therapy is diverse and multi-disciplinary. Engineers however, were late in joining the research movement and as such, engineering literature related to HIV chemotherapy is limited. Control engineers in particular, should have risen to the challenge, as it is apparent that HIV chemotherapy and control engineering have a lot in common. From a control theoretic point of view, HIV chemotherapy is control of a time varying nonlinear dynamical system with constrained controls. Once a suitable model has been developed or identified, control system theoretical concepts and design principles can be applied. The adopted control approach or strategy depends primarily on the control objectives, performance specifications and the control constraints. In principle, the designed control system can then be validated with clinical data. Obtaining measurements of the controlled variables however, has the potential to hinder effective control. The first part of this research focused on the application of control system analytical tools to HIV/AIDS models. The intention was to gain some insights into the HIV infection dynamics from a control theoretic perspective. The issues that needed to be addressed are: Persistent virus replication under potent HAART, variability in response to therapy between individuals on the same regimen, transient rebounds of plasma viremia after periods of suppression, the attainment, or lack thereof, of maximal and durable suppression of the viral load. The questions to answer were: When are the above mentioned observed responses to therapy most likely to occur as the HIV infection progresses, and does attaining one necessarily imply the other? Furthermore, the prognostic markers of virologic success, the possibility of individualizing therapy and timing the initiation of antiretroviral therapy such that the benefits of therapy are maximized, are matters that were also investigated. The primary objective of this thesis was to analyze models for the eventual control of the HIV infection. HIV therapy has multiple and often conflicting objectives, and these objectives had to be prioritized. The intention of the proposed control strategy was to produce practical solutions to the current antiretroviral problems. To this end, the second part of the research focused on addressing the HIV/AIDS control issues of sampling for effective control given the invasive nature of drawing blood from a patient and the derivation of drug dosage sequences to strike a balance between maximal suppression and toxicity reduction, when multiple drugs are concomitantly used to treat the infection. Electrical, Electronic and Computer Engineering Unrestricted 2013-09-07T18:55:01Z 2006-12-15 2013-09-07T18:55:01Z 2006-09-05 2006-12-15 2006-12-15 Thesis Jeffrey, A 2006, A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/30379 > http://hdl.handle.net/2263/30379 http://upetd.up.ac.za/thesis/available/etd-12152006-104428/ © 2006, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf University of Pretoria |
| spellingShingle | Hiv/aids models HIV immunology Initiate HIV therapy HIV/AIDS model analysis Biomedical engineering Model predictive control Control engineering in medicine Immune based therapy Protocol design Structured treatment interruption Drug dosage design UCTD A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title | A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title_full | A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title_fullStr | A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title_full_unstemmed | A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title_short | A control theoretic approach to HIV/AIdS drug dosage design and timing the initiation of therapy |
| title_sort | control theoretic approach to hiv aids drug dosage design and timing the initiation of therapy |
| topic | Hiv/aids models HIV immunology Initiate HIV therapy HIV/AIDS model analysis Biomedical engineering Model predictive control Control engineering in medicine Immune based therapy Protocol design Structured treatment interruption Drug dosage design UCTD |
| url | http://hdl.handle.net/2263/30379 http://upetd.up.ac.za/thesis/available/etd-12152006-104428/ |