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Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs
Dissertation (MSc)--University of Pretoria, 2010.
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University of Pretoria
2013
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| _version_ | 1867613623711432704 |
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| access_status_str | Open Access |
| author2 | Dzikiti, Tarisai Brighton |
| author_browse | Dzikiti, Tarisai Brighton |
| author_facet | Dzikiti, Tarisai Brighton |
| collection | Thesis |
| dc_rights_str_mv | © 2010 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria |
| description | Dissertation (MSc)--University of Pretoria, 2010. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/30505 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:05.758Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/30505 Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs Dzikiti, Tarisai Brighton Stegmann, Frik G. martins221@hotmail.com Suarez, Martin Alejandro Alfaxalone Propofol Anaesthesia Ovariohysterectomy in dogs UCTD Dissertation (MSc)--University of Pretoria, 2010. Objective To compare the anaesthetic and cardiopulmonary effects of alfaxalone in comparison to propofol when used for total intravenous anaesthesia (TIVA) during ovariohysterectomy in dogs. Animals Fourteen healthy female crossbred dogs between 6 months and 5 years, with body weight between 16 - 42 kg. Methods All dogs were premedicated with acepromazine 0.01 mg/kg and morphine 0.4 mg/kg subcutaneously. Anaesthesia was induced and maintained with either Group 1- propofol (6 mg/kg followed by 0.3-0.5 mg/kg/min intravenously) or Group 2 alfaxalone (2 mg/kg followed 0.10-0.12 mg/kg/min intravenously). Quality of induction and recovery were determined. Dogs were spontaneously breathing 100 % oxygen. Respiratory and cardiovascular parameters were measured: Respiratory rate (RR), end tidal CO2 (ETCO2), tidal volume (TV). Heart rate (HR), systolic (SAP), diastolic (DAP), and mean arterial blood pressure (MAP). Arterial blood samples were collected during and after the surgery to determinate arterial PH, PaCO2, PaO2. Results Smooth and rapid induction followed by satisfactory maintenance and good recovery quality was observed with both anaesthetic agents. Cardiopulmonary effects were similar for both groups with notable respiratory depression and fair hemodynamic parameters. Conclusions and Clinical Relevance The administration of alfaxalone used as TIVA in premedicated dogs produced satisfactory anaesthesia with the same quality as that produced by propofol during ovariohysterectomy. Hypoventilation was the most prominent adverse effect from both anaesthetic agents suggesting a need for ventilatory support during prolonged TIVA periods with either anaesthetic agent. Companion Animal Clinical Studies unrestricted 2013-09-07T19:13:25Z 2010-12-21 2013-09-07T19:13:25Z 2010-11-26 2010-12-21 2010-12-21 Dissertation Suarez, MA 2010, Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/30505 > E10/892/gm http://hdl.handle.net/2263/30505 http://upetd.up.ac.za/thesis/available/etd-12212010-181452/ © 2010 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria application/pdf University of Pretoria |
| spellingShingle | Alfaxalone Propofol Anaesthesia Ovariohysterectomy in dogs UCTD Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title | Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title_full | Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title_fullStr | Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title_full_unstemmed | Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title_short | Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| title_sort | comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs |
| topic | Alfaxalone Propofol Anaesthesia Ovariohysterectomy in dogs UCTD |
| url | http://hdl.handle.net/2263/30505 http://upetd.up.ac.za/thesis/available/etd-12212010-181452/ |