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Enantioanalysis of pharmaceutical compounds
Dissertation (MSc (Chemistry))--University of Pretoria, 2007.
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| Format: | Thesis |
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University of Pretoria
2013
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| _version_ | 1867613667071098880 |
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| access_status_str | Open Access |
| author2 | Stefan, Raluca-Ioana |
| author_browse | Stefan, Raluca-Ioana |
| author_facet | Stefan, Raluca-Ioana |
| collection | Thesis |
| dc_rights_str_mv | © 2006, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Chemistry))--University of Pretoria, 2007. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/30557 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:47.098Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/30557 Enantioanalysis of pharmaceutical compounds Stefan, Raluca-Ioana s25474830@tuks.co.za Mashile, Tumelo Rameleko Enantioanalysis Pharmaceutical Compounds UCTD Dissertation (MSc (Chemistry))--University of Pretoria, 2007. Due to the differences in pharmacokinetics and pharmacodynamics of the enantiomers of the same chiral pharmaceutical substance, there is a high need of reliable analytical methods for enantiopurity tests of them in the raw material as well as in its pharmaceutical formulations. If some of the chiral pharmaceutical compounds can be delivered as racemates, there are many others for which the enantiopurity is essential. Enantioanalysis using enantioselective, potentiometric membrane electrodes became a good alternative of the chromatographic methods due to its high reliability. To have reliable analytical information it is necessary to use reliable analytical methods and electrodes. The most reliable design for the enantioselective, potentiometric membrane electrodes proved to be the one based on carbon paste. This electrodes are made by mixing graphite powder with paraffin oil to give carbon paste, which is modified by the addition of a chiral selector (e.g., cylodextrins, maltodextrins, macrocyclic antibiotics and fullerenes). The high sensitivity, selectivity, enantioselectivity, accuracy and precision made the enantioselective, potentiometric membrane electrodes suitable to be used for the enantioanalysis of different pharmaceutical compounds such as S- and R-deprenyl and S-ibuprofen as raw materials and in their pharmaceutical formulations. Chemistry unrestricted 2013-09-07T19:20:26Z 2007-02-22 2013-09-07T19:20:26Z 2006-04-24 2007-02-22 2007-02-22 Dissertation Mashile, T 2006, Enantioanalysis of pharmaceutical compounds, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/30557 > http://hdl.handle.net/2263/30557 http://upetd.up.ac.za/thesis/available/etd-02222007-195248/ © 2006, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf University of Pretoria |
| spellingShingle | Enantioanalysis Pharmaceutical Compounds UCTD Enantioanalysis of pharmaceutical compounds |
| title | Enantioanalysis of pharmaceutical compounds |
| title_full | Enantioanalysis of pharmaceutical compounds |
| title_fullStr | Enantioanalysis of pharmaceutical compounds |
| title_full_unstemmed | Enantioanalysis of pharmaceutical compounds |
| title_short | Enantioanalysis of pharmaceutical compounds |
| title_sort | enantioanalysis of pharmaceutical compounds |
| topic | Enantioanalysis Pharmaceutical Compounds UCTD |
| url | http://hdl.handle.net/2263/30557 http://upetd.up.ac.za/thesis/available/etd-02222007-195248/ |