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Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection
Dissertation (MSc)--University of Pretoria, 2013.
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| Format: | Thesis |
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University of Pretoria
2014
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| _version_ | 1867613661955096576 |
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| access_status_str | Open Access |
| author2 | Rheeder, Paul |
| author_browse | Rheeder, Paul |
| author_facet | Rheeder, Paul |
| collection | Thesis |
| description | Dissertation (MSc)--University of Pretoria, 2013. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/33504 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:39:42.090Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/33504 Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection Rheeder, Paul justintshenje@yahoo.com Mayosi, Bongani M. Shenje, Justin Tapiwa Tuberculosis Pericarditis UCTD Baseline characteristics TB pericarditis HIV co-infection C14/4/165/gm Dissertation (MSc)--University of Pretoria, 2013. Introduction: Tuberculosis (TB) pericarditis is a relatively rare form of tuberculosis which has been on the decline. However, the advent of the human immunodeficiency virus (HIV) pandemic has brought about the resurgence of tuberculosis pericarditis and an even poorer prognosis for patients with HIV co-infection. Objectives: The aim is to describe the baseline characteristics of tuberculous pericarditis patients and to assess the impact of HIV on the clinical presentation of this disease. Methods: The study describes baseline data from a randomised clinical trial which explored the use of adjunctive corticosteroids in management of TB pericarditis then went on to compare HIV co-infected patients versus those without HIV co-infection using logistic regression. Results: There were 1394 patients enrolled into the study, 64% were HIV positive, 19% were HIV negative and 17% had an unknown HIV status. Forty four percent of the participants were female and age had a positively skewed distribution with median 36 years (IQR: of 29-46). HIV co-infected patients were younger with OR 0.97(95% CI: 0.96-0.98), more likely to have previously had TB with OR 2.15(95% CI: 1.25-3.72), had a more acute illness with OR 0.99(95% CI: 0.99-1.00), had lower hemoglobin with OR 0.72(95% CI: 0.67-0.78), lower White Cell Count, (WCC) with OR 0.90(95% CI: 0.86-0.96) and higher globulin with OR 1.07(95% CI: 1.05-1.09). Conclusion: HIV co-infected participants are younger, more likely to have been previously diagnosed with TB, have a more acute illness, lower haemoglobin, lower WCC and higher globulin. School of Health Systems and Public Health (SHSPH) unrestricted 2014-02-18T06:51:21Z 2014-02-18T06:51:21Z © 2013 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. 2014 2013 Dissertation Shenje, JTS 2013, Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd<http://hdl.handle.net/2263/33504> http://hdl.handle.net/2263/33504 application/pdf University of Pretoria |
| spellingShingle | Tuberculosis Pericarditis UCTD Baseline characteristics TB pericarditis HIV co-infection C14/4/165/gm Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title | Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title_full | Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title_fullStr | Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title_full_unstemmed | Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title_short | Tuberculous pericarditis in HIV co-infected compared to those without HIV co-infection |
| title_sort | tuberculous pericarditis in hiv co infected compared to those without hiv co infection |
| topic | Tuberculosis Pericarditis UCTD Baseline characteristics TB pericarditis HIV co-infection C14/4/165/gm |
| url | http://hdl.handle.net/2263/33504 |