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The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis
Dissertation (MMedVet)--University of Pretoria, 2013.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2014
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| _version_ | 1867613614212382720 |
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| access_status_str | Open Access |
| author2 | Leisewitz, Andrew L. |
| author_browse | Leisewitz, Andrew L. |
| author_facet | Leisewitz, Andrew L. |
| collection | Thesis |
| dc_rights_str_mv | © 2013 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet)--University of Pretoria, 2013. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/36786 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:56.612Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/36786 The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis Leisewitz, Andrew L. rkburchell@gmail.com Schoeman, Johan P. Burchell, Richard K. Canine parvoviral enteritis Assess acid-base changes in puppies Animals Infection UCTD CPV Dissertation (MMedVet)--University of Pretoria, 2013. The acid-base disturbances in Canine Parvoviral Enteritis (CPV) are not well described. In addition the mechanisms causing these perturbations have not been fully elucidated. The purpose of this study was to assess acid-base changes in puppies suffering from Canine Parvoviral Enteritis (CPV) using a Modified Strong Ion Model (SIM). The hypothesis of this study was that severe acid-base disturbances would be present and that the SIM would provide patho-mechanistic insights that would not be fully appreciated by the Henderson-Hasselbalch model. The study retrospectively analysed data obtained from 42 puppies with confirmed CPV and 12 healthy controls. The CPV group had been allocated a clinical score to allow classification of the data according to clinical severity. The effects of changes in free water, chloride, lactate, albumin and phosphate were calculated using a modification of the base excess algorithm. The data for each of these variables was compared to the control group. When the data were summated for each patient and correlated to each individual component, the most important contributor to the metabolic acid-base changes according to SIM was chloride (P < 0.001). Severely affected animals tended to have a hypochloraemic alkalosis, whereas mildly effected puppies had a hyperchloraemic acidosis (P = 0.0023). In conclusion the acid base disturbances in CPV are multifactorial and complex and the SIM provides more information regarding the origin of these changes. gm2014 Companion Animal Clinical Studies unrestricted 2014-02-26T11:18:09Z 2014-02-26T11:18:09Z 2013-09-06 2013 Dissertation Burchell, RK 2013, The role of SID and ATOT in the metabolic acid-base changes of Canine Parvoviral Enteritis, MMedVet dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/36786> E13/9/1136/gm http://hdl.handle.net/2263/36786 en © 2013 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Canine parvoviral enteritis Assess acid-base changes in puppies Animals Infection UCTD CPV The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title | The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title_full | The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title_fullStr | The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title_full_unstemmed | The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title_short | The role of SID and ATOT in the metabolic acid-base changes of canine parvoviral enteritis |
| title_sort | role of sid and atot in the metabolic acid base changes of canine parvoviral enteritis |
| topic | Canine parvoviral enteritis Assess acid-base changes in puppies Animals Infection UCTD CPV |
| url | http://hdl.handle.net/2263/36786 |