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A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice
Dissertation (MSc)--University of Pretoria, 2013.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2014
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| _version_ | 1867613703037255681 |
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| access_status_str | Open Access |
| author2 | Muntingh, George L. |
| author_browse | Muntingh, George L. |
| author_facet | Muntingh, George L. |
| collection | Thesis |
| dc_rights_str_mv | © 2013 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2013. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/40699 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:21.476Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/40699 A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice Muntingh, George L. Finberg, Marike Johanna Atopic dermatitis (AD) Balb/c mice Treatment Corticosteroids Aloe ferox Aloe vera Dinitrofluorobenzene Adverse event UCTD Dissertation (MSc)--University of Pretoria, 2013. Atopic dermatitis (AD) typically develops in patients with a history of allergic ailments, and is characterised by an itchy, inflammatory skin condition with scaling, lichenification, papules, excoriations and pruritus. In AD patients a chronic relapsing inflammatory condition is seen, associated with IgE hyper production. AD flares are largely triggered by environmental factors. However, the exact etiology of AD is unclear and there is a pressing need for new treatment regimens as AD is a chronic condition and requires long term treatment. Historically Aloe has been used to treat skin conditions as well as a variety of other diseases. To further explore the pathogenesis and treatment of AD, Balb/c mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB) for atopic dermatitis induction. Thereafter, mice were treated with either Aloe ferox or Aloe vera applied daily on the dorsal skin for 10 consecutive days. A placebo gel was used for the control mice. Blood was collected at the end of the treatment period and serum IgE levels measured. Serum IgE levels were significantly lowered in the Aloe ferox group than in the Aloe vera group. This study demonstrated Aloe’s immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation. gm2014 Pharmacology unrestricted 2014-07-11T06:20:25Z 2014-07-11T06:20:25Z 2014-04-25 2013 Dissertation Finberg, M J 2013, A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/40699> E14/4/273/gm http://hdl.handle.net/2263/40699 en © 2013 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Atopic dermatitis (AD) Balb/c mice Treatment Corticosteroids Aloe ferox Aloe vera Dinitrofluorobenzene Adverse event UCTD A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title | A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title_full | A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title_fullStr | A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title_full_unstemmed | A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title_short | A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice |
| title_sort | comparative study for the topical treatment of atopic dermatitis with aloe ferox and aloe vera in balb c mice |
| topic | Atopic dermatitis (AD) Balb/c mice Treatment Corticosteroids Aloe ferox Aloe vera Dinitrofluorobenzene Adverse event UCTD |
| url | http://hdl.handle.net/2263/40699 |