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Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies
Dissertation (MMedVet)--University of Pretoria, 2014.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2014
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| _version_ | 1867613564396634112 |
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| access_status_str | Open Access |
| author2 | Saulez, Montague Newton |
| author_browse | Saulez, Montague Newton |
| author_facet | Saulez, Montague Newton |
| collection | Thesis |
| dc_rights_str_mv | © 2014 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet)--University of Pretoria, 2014. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/40705 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:08.659Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/40705 Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies Saulez, Montague Newton adrienne.viljoen@up.ac.za Page, Patrick Collin Viljoen, Adrienne Horses Pony mares Thromboelastography variables Bile acid concentrations UCTD Dissertation (MMedVet)--University of Pretoria, 2014. This dissertation describes the effects of tetrastarch (130/0.4) on serum colloid osmotic pressure and thromboelastography variables in healthy pony mares. Additional variables assessed during this study included markers of haemodilution (PCV, TS) and serum creatinine and bile acid concentrations. Six clinically healthy Nooitgedacht pony mares were utilized in a crossover study design. Tetrastarch (130/0.4) was administered at 10, 20 and 40 ml/kg bwt to each mare in a random sequence with a two week washout period between each of the treatments. Packed cell volume (PCV), plasma total solids (TS), serum colloid osmotic pressure (COP), and platelet count were measured and thromboelastography (TEG) was performed before treatment (baseline), immediately after infusion (time 0), and 1, 6, 12, 24, 48, and 96 h after tetrastarch infusion. All TEG variables remained within reference range in all treatment groups. Administration of tetrastarch at 40 ml/kg bwt resulted in a prolonged K-time at 6 h post-infusion, and decreased maximum amplitude at 0, 1, 6, 24 and 48 h post-infusion compared to baseline. Administration of tetrastarch increased mean COP values above baseline in all three treatment groups, persisting to 24, 6 and 48 h after treatment with 10, 20 and 40 ml/kg of tetrastarch respectively. This study concluded that, although values remained within established reference ranges, the administration of tetrastarch (130/0.4) at 40 ml/kg bwt is more likely to induce changes in TEG variables than doses of 20 ml/kg or less. Tetrastarch increased COP in healthy horses at all evaluated dose rates. gm2014 Companion Animal Clinical Studies unrestricted 2014-07-11T06:21:37Z 2014-07-11T06:21:37Z 2014-04-11 2014 Dissertation Viljoen, A 2014, Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies, MMedVet dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/40705> E14/4/259/gm http://hdl.handle.net/2263/40705 en © 2014 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Horses Pony mares Thromboelastography variables Bile acid concentrations UCTD Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title | Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title_full | Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title_fullStr | Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title_full_unstemmed | Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title_short | Coagulation, oncotic and haemodilutional effects of a third generation hydroxyethyl starch (130/0.4) in ponies |
| title_sort | coagulation oncotic and haemodilutional effects of a third generation hydroxyethyl starch 130 0 4 in ponies |
| topic | Horses Pony mares Thromboelastography variables Bile acid concentrations UCTD |
| url | http://hdl.handle.net/2263/40705 |