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A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome
Dissertation (MSc)--University of Pretoria, 2014.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2015
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| _version_ | 1867613704763211776 |
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| access_status_str | Open Access |
| author2 | Dzikiti, Loveness Nyaradzo |
| author_browse | Dzikiti, Loveness Nyaradzo |
| author_facet | Dzikiti, Loveness Nyaradzo |
| collection | Thesis |
| dc_rights_str_mv | © 2014 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2014. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/43211 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:23.116Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/43211 A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome Dzikiti, Loveness Nyaradzo olinger274@gmail.com Rheeder, Paul Olinger, Lynda UCTD Dissertation (MSc)--University of Pretoria, 2014. Background: This study compares three methodologies appropriate for the analysis of longitudinal time-to-event data. The Cox model is well researched and frequently used. Threshold regression, however, is relatively new and there are few articles describing its application in biomedical statistics. A linear mixed model provides an alternative interpretation of a continuous outcome rather than time to an event. A longitudinal study of the time to onset of diabetic nephropathy, a common complication of Diabetes Mellitus, is used to compare the three models with respect to their explanatory and predictive abilities and utilitarian value to researchers. Methods: The study entails a secondary data analysis of 1160 retrospective patient records, collected at a diabetic clinic at Kalafong Hospital, Pretoria. Model selection was based on current literature, backward elimination of insignificant variables (p>0.2) and the Akaike and Bayesian Information Criterion. Survival and hazard functions and ratios were determined for the survival data. Risk categories in the Cox model evaluated discrimination, while threshold regression predicted survival probabilities for specific patient profiles. The linear mixed model predicted albumin-creatinine ratio values, a marker for the diagnosis of diabetic nephropathy. Results: The Cox model, stratified by glucose control, gender, hypertension, type of diabetes and smoking status, had an AIC of 81 and was the most parsimonious model. Threshold regression, with an AIC of 1428, indicated duration of diabetes as a significant factor in the process of health deterioration. Individual variation in weight and total cholesterol amongst patients was accounted for by the linear mixed model, with an AIC of 3755. Conclusion: All three regression models provided valuable insight into underlying risk factors of diabetic nephropathy and should form part of a multi-faceted approach to analysing longitudinal survival data. lk2014 School of Health Systems and Public Health (SHSPH) MSc Unrestricted 2015-01-19T12:11:16Z 2015-01-19T12:11:16Z 2014/12/12 2014 Dissertation Olinger, L 2014, A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome, MSc Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/43211> M14/9/394 http://hdl.handle.net/2263/43211 en © 2014 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title | A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title_full | A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title_fullStr | A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title_full_unstemmed | A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title_short | A Comparison of Survival Analysis, Threshold Regression and Linear Mixed Models in a Longitudinal Diabetes Clinic Study (2009 – 2013) at Kalafong Hospital with Nephropathy as Outcome |
| title_sort | comparison of survival analysis threshold regression and linear mixed models in a longitudinal diabetes clinic study 2009 2013 at kalafong hospital with nephropathy as outcome |
| topic | UCTD |
| url | http://hdl.handle.net/2263/43211 |