Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy
Dissertation (MPhyst)--University of Pretoria, 2015.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2015
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613622844260352 |
|---|---|
| access_status_str | Open Access |
| author2 | Eksteen, Carina A. |
| author_browse | Eksteen, Carina A. |
| author_facet | Eksteen, Carina A. |
| collection | Thesis |
| dc_rights_str_mv | © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MPhyst)--University of Pretoria, 2015. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/43774 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:04.809Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/43774 A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy Eksteen, Carina A. Pepper, Michael Sean Skeen, Melanie Spinal cord injuries Rehabilitation Stem cells Physical rehabilitation UCTD Evidence-based medicine Clinical trials Health sciences theses SDG-03 Health sciences theses SDG-10 Health sciences theses SDG-16 Health sciences theses SDG-17 Dissertation (MPhyst)--University of Pretoria, 2015. A spinal cord injury (SCI) can result in severe dysfunction and disability. Stem cell therapy is seen as a potential means of promoting healing and improving function in persons with spinal cord injuries. Methods and Subjects: Persons with SCI in South Africa who had received stem cell therapy outside of registered clinical trials were identified. Data was collected on the nature of the injury, its treatment and cost. The Spinal Cord Independence Measure (SCIM) III was used as a measure of the recipients’ functional status. Results: Comparisons were drawn between the impairment and functional ability pre- and post-stem cell treatment and the expected outcome level for the specific lesion. Stem cell sources were autologous, allogeneic or xenogeneic. Costs ranged from 0 to 700 000 South African Rands. Following the stem cell therapy there was no significant improvement in SCIM III or ASIA scores. Conclusion: No evidence exists that current ‘stem cell’ therapies administered outside of registered clinical trials for persons with SCI are beneficial. Education of both patients and health professionals is required for ensuring that correct information is transmitted and for avoiding unrealistic expectations, bogus therapies and potential adverse effects. Ethical research is to be encouraged in the field of SCI. em2026 Physiotherapy MPhyst Unrestricted SDG-03: Good health and well-being SDG-10: Reduced inequalities SDG-16: Peace, justice and strong institutions SDG-17: Partnerships for the goals 2015-02-23T12:14:40Z 2015-02-23T12:14:40Z 2015-04-17 2015 Dissertation * A2015 http://hdl.handle.net/2263/43774 en © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Spinal cord injuries Rehabilitation Stem cells Physical rehabilitation UCTD Evidence-based medicine Clinical trials Health sciences theses SDG-03 Health sciences theses SDG-10 Health sciences theses SDG-16 Health sciences theses SDG-17 A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title | A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title_full | A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title_fullStr | A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title_full_unstemmed | A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title_short | A critical analysis of the functional outcome of persons with a spinal cord injury after ‘stem cell’ therapy |
| title_sort | critical analysis of the functional outcome of persons with a spinal cord injury after stem cell therapy |
| topic | Spinal cord injuries Rehabilitation Stem cells Physical rehabilitation UCTD Evidence-based medicine Clinical trials Health sciences theses SDG-03 Health sciences theses SDG-10 Health sciences theses SDG-16 Health sciences theses SDG-17 |
| url | http://hdl.handle.net/2263/43774 |