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Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study
Dissertation (MPH)--University of Pretoria, 2014.
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| Other Authors: | |
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2015
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| _version_ | 1867613480406745088 |
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| access_status_str | Open Access |
| author2 | Beke, Andy |
| author_browse | Beke, Andy |
| author_facet | Beke, Andy |
| collection | Thesis |
| dc_rights_str_mv | © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MPH)--University of Pretoria, 2014. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/46150 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:49.219Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/46150 Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study Beke, Andy Shabangu, Patrick L. UCTD Dissertation (MPH)--University of Pretoria, 2014. Objectives: To evaluate effectiveness of Anti-Retroviral Therapy (ART) services on clinical outcomes and survival of HIV infected children [0-15 years) in Swaziland. Study design: A retrospective cohort analysis of medical records for 4170 HIV-infected children who were initiated on ART between 2004 and 2008 was conducted. The Signed-ranks test, Kaplan Meier Estimator, and Cox-P H regression model were used to compare clinical outcomes between relevant predictors. Results: The results reveal that clinical outcomes for HIV-infected children on ART were desirable as indicated by significant CD4 gain (from 17 CD4% to 35 CD4%, 14 CD4% to 34 CD4%, and from 194 to 592 CD4 count in mm3 for children aged [0-2) years, [2-5) years and [5-15) years, respectively, p<=0.001). Early initiated children were dying at a rate estimated to be 67% times lower than children who were delayed ART (p-value<=0.001). Children within the age group of [2-5) years had higher hazard (HR=1.59, 95% CI: 1.33-1.89) of death than children within the age group of [5-15) years. Conclusions: The ART paediatric programme in Swaziland proved to be effective as demonstrated by positive clinical outcomes. Early initiation proved to be effective in increasing survival time for children. tm2015 School of Health Systems and Public Health (SHSPH) MPH Unrestricted 2015-07-02T11:06:59Z 2015-07-02T11:06:59Z 2015/04/23 2014 Dissertation Shabangu, PL 2014, Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study, MPH Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/46150> A2015 http://hdl.handle.net/2263/46150 en © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title | Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title_full | Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title_fullStr | Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title_full_unstemmed | Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title_short | Survival of children on Antiretroviral Therapy in Swaziland : a retrospective cohort study |
| title_sort | survival of children on antiretroviral therapy in swaziland a retrospective cohort study |
| topic | UCTD |
| url | http://hdl.handle.net/2263/46150 |