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In silico discovery of novel cytotoxic T-lymphocyte epitopes in the HIV-1 Pol region in response to antiretroviral resistance mutations
Thesis (PhD)--University of Pretoria, 2014.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2015
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| _version_ | 1867613654612967424 |
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| access_status_str | Open Access |
| author2 | Joubert, Fourie |
| author_browse | Joubert, Fourie |
| author_facet | Joubert, Fourie |
| collection | Thesis |
| dc_rights_str_mv | © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2014. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/46185 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:35.267Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/46185 In silico discovery of novel cytotoxic T-lymphocyte epitopes in the HIV-1 Pol region in response to antiretroviral resistance mutations Joubert, Fourie Smidt, Werner UCTD Thesis (PhD)--University of Pretoria, 2014. The Acquired Immunode ciency Syndrome pandemic continues to have a large social impact. Many advances in the treatment of infection by the causative agent, Human Immunode ciency Virus, have been made in the last three decades. However, this treatment often means a life-long rigorous adherence to treatment and acquisition of resistance mutations to antiretrovirals. Thus far, the e cacy of promising vaccines has been disappointing. In the last decade, interest has grown concerning the interaction between mutations conferring resistance to antiretrovirals and the e ect this has on epitopes recognized by cytotoxic-T-lymphocytes (CTL). Investigating this is a di cult task, owing to both the extreme polymorphism of HIV and the polymorphism of the Human Leukocyte Antigen (HLA) molecules that present peptides to the CTLs. A large amount of HLA-associated CTL escape mutations have been discovered. Together with this, computational approaches in CTL epitope discovery is becoming increasingly accurate. Here, a method of imputing HLA type from patients together with predicting the in uence of anitretroviral mutations was used to discover potential epitopes for the HLA B*15 and B*48 types in the HIV-1 Subtype B pol region. tm2015 Biochemistry PhD Unrestricted 2015-07-02T11:07:06Z 2015-07-02T11:07:06Z 2015/04/22 2014 Thesis Smidt, W 2014, In silico discovery of novel cytotoxic T-lymphocyte epitopes in the HIV-1 Pol region in response to antiretroviral resistance mutations, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/46185> A2015 http://hdl.handle.net/2263/46185 en © 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD In silico discovery of novel cytotoxic T-lymphocyte epitopes in the HIV-1 Pol region in response to antiretroviral resistance mutations |
| title | In silico discovery of novel cytotoxic T-lymphocyte epitopes in
the HIV-1 Pol region in response to antiretroviral resistance
mutations |
| title_full | In silico discovery of novel cytotoxic T-lymphocyte epitopes in
the HIV-1 Pol region in response to antiretroviral resistance
mutations |
| title_fullStr | In silico discovery of novel cytotoxic T-lymphocyte epitopes in
the HIV-1 Pol region in response to antiretroviral resistance
mutations |
| title_full_unstemmed | In silico discovery of novel cytotoxic T-lymphocyte epitopes in
the HIV-1 Pol region in response to antiretroviral resistance
mutations |
| title_short | In silico discovery of novel cytotoxic T-lymphocyte epitopes in
the HIV-1 Pol region in response to antiretroviral resistance
mutations |
| title_sort | in silico discovery of novel cytotoxic t lymphocyte epitopes in the hiv 1 pol region in response to antiretroviral resistance mutations |
| topic | UCTD |
| url | http://hdl.handle.net/2263/46185 |