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Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa
Dissertation (MSc)--University of Pretoria, 2015.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2016
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| _version_ | 1867613500435595264 |
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| access_status_str | Open Access |
| author2 | Abolnik, Celia |
| author_browse | Abolnik, Celia |
| author_facet | Abolnik, Celia |
| collection | Thesis |
| dc_rights_str_mv | © 2016 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2015. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/53310 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:08.286Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/53310 Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa Abolnik, Celia dionne@deltamune.co.za Rauff, Dionne Lynda UCTD Dissertation (MSc)--University of Pretoria, 2015. "Does the current H6N2 vaccine still offer sufficient protection?" is a fundamental question asked by the poultry industry in South Africa today. In this study we advanced our understanding of the genetic drift of the H6N2 virus in poultry in South Africa, by phylogenetic analyses of gene segments and antigenic characterization of the virus, and determined the efficacy of the current vaccine. Using isolates collected between 2002 and 2013, full genome sequencing was performed to determine whether genetic re-assortment had occurred over the past decade. Vaccine batches were made from these isolates and with the use of antigenic cartography the haemagglutination inhibition (HI) data was visualized to determine antigenic similarities or differences between the viruses. From this research, information about the evolution of the H6N2 virus was revealed. The findings show that although extensive genetic drift has occurred over the last ten years and two distinct sub-lineages have developed, the current vaccine will still offer sufficient protection for both sub-lineages of H6N2 viruses. Keywords: avian influenza virus, poultry, H6N2, genetic drift tm2016 Veterinary Tropical Diseases MSc 2016-06-22T08:00:43Z 2016-06-22T08:00:43Z 2016-04-21 2015 Dissertation Rauff, DL 2015, Molecular and antigenic characterisation of H6N2 avian influenza viruses isolated in South Africa, MSc Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/53310> A2016 http://hdl.handle.net/2263/53310 en © 2016 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title | Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title_full | Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title_fullStr | Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title_full_unstemmed | Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title_short | Molecular and antigenic characterization of H6N2 avian influenza viruses isolated in South Africa |
| title_sort | molecular and antigenic characterization of h6n2 avian influenza viruses isolated in south africa |
| topic | UCTD |
| url | http://hdl.handle.net/2263/53310 |