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Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs
Mini Dissertation (MMedVet)--University of Pretoria, 2016.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2017
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| _version_ | 1867613641643130880 |
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| access_status_str | Open Access |
| author2 | Zeiler, Gareth Edward |
| author_browse | Zeiler, Gareth Edward |
| author_facet | Zeiler, Gareth Edward |
| collection | Thesis |
| dc_rights_str_mv | © 2017 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Mini Dissertation (MMedVet)--University of Pretoria, 2016. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/60280 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:22.809Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/60280 Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs Zeiler, Gareth Edward u23023270@tuks.co.za Hartman, Marthinus Jacobus Smalle, Tesh Michelle UCTD Anaesthetic protocol Canine Laryngeal paralysis Laryngoscopy Mini Dissertation (MMedVet)--University of Pretoria, 2016. Objective: To compare the effects of thiopental, propofol and alfaxalone on arytenoid cartilage motion and establish dose rates to achieve a consistent oral laryngoscopy examination. Study design: Prospective, randomised, blinded crossover study. Animals: Six healthy adult beagle dogs. Methods: Each dog was administered three induction agents in a random order with a one week washout period between treatments. No premedication was used prior to induction of anaesthesia. Thiopental, propofol or alfaxalone were administered at 7.5 mg/kg, 3 mg/kg and 1.5 mg/kg, over 1 minute to effect, for induction of anaesthesia, respectively. If the dog was deemed inadequately anaesthetised then top-up boluses of 1.8 mg/kg, 0.75 mg/kg and 0.4 mg/kg, respectively, were administered over 10 seconds, repeated every 20 seconds, until an adequate anaesthetic plane had been reached. Continual examination of the larynx, using a laryngoscope, commenced once an adequate anaesthetic depth had been reached until recovery from anaesthesia. The number of arytenoid motions and deep inspiratory efforts (vital breaths) were counted within three time periods and compared over time among treatments. Data were analysed using Friedman test, Mann-Whitney U test, Spearman's rho, linear mixed model with post-hoc pairwise comparison with Tukey correction. Results interpreted at a 5% level of significance. Results: The median (range) induction time was 2.8 (2.0, 3.0), 2.7 (2.0, 3.3) and 2.5 (1.7, 3.3) minutes for thiopental, propofol and alfaxalone, respectively (p = 0.727). The median (range) dose rate required to achieve an adequate depth of anaesthesia was 6.3 (6.0, 6.6), 2.4 (2.4, 2.4) and 1.2 (1.2, 1.2) mg/kg/minute for thiopental, propofol and alfaxalone, respectively. Therefore, the median (range) total dose administered over the induction time was 17.8 (13.2, 18.8), 6.8 (5.3, 8.3) and 3.2 (2.3, 4.1) mg/kg for thiopental, propofol and alfaxalone, respectively. There was no significant difference for the total number of arytenoid motions (p =0.662) or vital breaths (p = 0.789) among induction agents. The median (range) examination times were 14.1 (8.0, 41.8), 5.4 (3.3, 14.8) and 8.5 (3.8, 31.6) minutes for thiopental, propofol and alfaxalone, respectively (p=0.016). Conclusion and clinical relevance: There was no significant difference in the total number of arytenoid motions among the induction agents. However, at the dose rates used in this study, propofol provided adequate conditions for evaluation of the larynx within a shorter examination time which may be advantageous during laryngoscopy in dogs. Companion Animal Clinical Studies MMedVet Unrestricted 2017-05-08T10:06:18Z 2017-05-08T10:06:18Z 2017-04-07 2016 Mini Dissertation Smalle, M 2016, Effects of thiopentone propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs, MMedVet Mini Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/60280> A2017 http://hdl.handle.net/2263/60280 en © 2017 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Anaesthetic protocol Canine Laryngeal paralysis Laryngoscopy Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title | Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title_full | Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title_fullStr | Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title_full_unstemmed | Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title_short | Effects of thiopental, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| title_sort | effects of thiopental propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs |
| topic | UCTD Anaesthetic protocol Canine Laryngeal paralysis Laryngoscopy |
| url | http://hdl.handle.net/2263/60280 |