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A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei
Thesis (DSc)--University of Pretoria, 1963.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2017
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| _version_ | 1867613699519283200 |
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| access_status_str | Open Access |
| author2 | Joubert, Fourie |
| author_browse | Joubert, Fourie |
| author_facet | Joubert, Fourie |
| collection | Thesis |
| dc_rights_str_mv | © 2017 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (DSc)--University of Pretoria, 1963. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/61727 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:18.073Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/61727 A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei Joubert, Fourie Grotepass, F.W.K. Verpoorte, Jacob Arnold UCTD Clostridium chauvoei Antigens Thesis (DSc)--University of Pretoria, 1963. The aim of the study described in this thesis was to obtain information about the chemical nature of the immunizing antigen of the vaccines against blackleg disease and the mechanism of the immunization. A literature study revealed the existence of much controversy about the reactions caused by Cl. chauvoei germs and toxins. Though the results of serological experiments carried out by various investigators led to the accepted theories about the relationships between homologous lethal toxins and haemolysins~ and between the haemolysis and other reactions of the two different species Cl. chauvoei and Cl. septicum, a comparative chemical study of the toxins had not yet been carried out. A preliminary investigation showed that the soluble immunizing antigen from the Cl. chauvoei cultures had the character of proteins. This was revealed by the loss of activity when pepsin and trypsin were allowed to act upon the antigenic solution and further by the influence of acid and heat upon the antigenic potency. No lethal activity was found in the filtrates of Cl. chauvoei (strain 64) cultures; instead we detected a haemolysin and a hyaluronidase which were also both heat-labile. The isolation procedures for the antigen and haemolysin relied on precipitation with ammonium sulphate and on chromatographic methods. Paraclinical Sciences DSc Unrestricted 2017-08-18T12:10:09Z 2017-08-18T12:10:09Z 1963 1963 Thesis Verpoorte, JA 1963, A biochemical stud of the soluble antigen and haemolysin of clostridium chauvoei, DSc Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/61727> http://hdl.handle.net/2263/61727 en © 2017 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Clostridium chauvoei Antigens A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title | A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title_full | A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title_fullStr | A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title_full_unstemmed | A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title_short | A biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| title_sort | biochemical study of the soluble antigen and haemolysin of clostridium chauvoei |
| topic | UCTD Clostridium chauvoei Antigens |
| url | http://hdl.handle.net/2263/61727 |