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Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis
Thesis (PhD)--University of Pretoria, 2018.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2018
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| _version_ | 1867613549693501440 |
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| access_status_str | Open Access |
| author2 | Pretorius, Etheresia |
| author_browse | Pretorius, Etheresia |
| author_facet | Pretorius, Etheresia |
| collection | Thesis |
| dc_rights_str_mv | © 2018 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2018. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/65529 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:55.093Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/65529 Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis Pretorius, Etheresia brandon.jackson@up.ac.za Mokoena, Taole Jackson, Brandon Spencer Surgery Physiology UCTD HIV Deep vein thrombosis (DVT) Hypercoagulability Blood coagulation Thrombosis Health sciences theses SDG-03 Health sciences theses SDG-17 Thesis (PhD)--University of Pretoria, 2018. Introduction: Patients infected with the Human immunodeficiency virus (HIV) are more prone to developing a hypercoagulable state. This may be due an upregulated inflammatory system resulting in a different coagulation profile. Aim(s): To compare the coagulation profile of HIV positive patients to HIV negative patients. Methods: A descriptive comparative prospective study recruiting symptomatic confirmed deep vein thrombosis (DVT) adult patients with HIV status. Patients blood samples were analysed using inflammatory markers, thromboelastogram, light microscopy smears and the scanning electron microscope. Results: DVT patients have a raised inflammatory profile and a hypercoagulable viscoelastic profile but no significant difference between HIV+ and HIV- groups. Ultrastructural changes of red blood cells, platelets and fibrin network are demonstrated in DVT patients. These changes were more extreme in the HIV positive patients. Conclusion: Patients with deep vein thrombosis are in a state of inflammation. HIV infection is linked to inflammation and inflammation is linked with a hypercoagulable state. HIV positive patients do have a different coagulation profile compared to HIV negative patients which can result in hypercoagulability and deep vein thrombosis. em2026 Surgery PhD Unrestricted SDG-03: Good health and well-being SDG-17: Partnerships for the goals 2018-07-16T07:25:38Z 2018-07-16T07:25:38Z 2018-09-07 2018 Thesis Jackson, BS 2018, Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/65529> S2018 http://hdl.handle.net/2263/65529 en © 2018 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Surgery Physiology UCTD HIV Deep vein thrombosis (DVT) Hypercoagulability Blood coagulation Thrombosis Health sciences theses SDG-03 Health sciences theses SDG-17 Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title | Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title_full | Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title_fullStr | Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title_full_unstemmed | Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title_short | Hypercoagulability using biophysical parameters in HIV positive versus HIV negative patients with deep vein thrombosis |
| title_sort | hypercoagulability using biophysical parameters in hiv positive versus hiv negative patients with deep vein thrombosis |
| topic | Surgery Physiology UCTD HIV Deep vein thrombosis (DVT) Hypercoagulability Blood coagulation Thrombosis Health sciences theses SDG-03 Health sciences theses SDG-17 |
| url | http://hdl.handle.net/2263/65529 |