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Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs
Dissertation (MSc)--University of Pretoria, 2018.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2019
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| _version_ | 1867613568672727040 |
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| access_status_str | Open Access |
| author2 | Stegmann, George Frik |
| author_browse | Stegmann, George Frik |
| author_facet | Stegmann, George Frik |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2018. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/70606 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:13.361Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/70606 Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs Stegmann, George Frik u17231249@tuks.co.za Zeiler, Gareth Edward Khanzadeh Alishahi, Majid UCTD Dissertation (MSc)--University of Pretoria, 2018. Objective To determine if intraperitoneal (IP) ropivacaine in conjunction with systemic analgesics improves postoperative analgesia following ovariohysterectomy (OHE) in dogs. Study Design Randomized, blinded, clinical trial. Animals Twenty dogs presented to the Veterinary Academic Hospital for elective OHE. Methods Dogs were premedicated with acepromazine (0.03 mg kg-1) and morphine (0.3 mg kg-1) intramuscularly (IM). Anaesthesia was induced with propofol (4 mg kg-1) intravenously (IV) and maintained with isoflurane (2%) in oxygen. Dogs were randomly assigned into one of two groups: group R received ropivacaine (n=10; 1 mg kg-1) and group S received 0.9 % saline (n=10; 0.1 mL kg-1) IP after linea alba incision. All OHE were performed by the same experienced surgeon. At completion of surgery, carprofen was administered IM at 4.4 mg kg-1. Pain was assessed using a mechanical nociceptive threshold (MNT) device before premedication, 30 minutes after premedication, as well as 2, 4 and 20 hours postextubation. Categorical data were analyzed using Fisher exact tests. Baseline quantitative data were compared between groups using Mann-Whitney U tests. Pain responses were compared between treatments using linear mixed models and post hoc comparisons were adjusted using Bonferroni correction of p-values. Results There were no significant differences (p>0.05) between the treatment groups regarding breed, age and weight. The effect of ropivacaine treatment to pressure required to elicit a pain response was not statistically significant different from saline. No adverse effects were observed following IP ropivacaine. Conclusions and clinical relevance IP administration of 1 mg kg-1 ropivacaine in conjunction with systemic analgesics did not improve postoperative analgesia following OHE in the dog. Companion Animal Clinical Studies MSc Unrestricted 2019-07-08T09:47:00Z 2019-07-08T09:47:00Z 2019/04/04 2018 Dissertation Khanzadeh Alishahi, M 2018, Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs, MSc Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/70606> A2019 http://hdl.handle.net/2263/70606 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title | Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title_full | Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title_fullStr | Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title_full_unstemmed | Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title_short | Evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| title_sort | evaluation of intraperitoneal ropivacaine for postoperative analgesia following ovariohysterectomy in dogs |
| topic | UCTD |
| url | http://hdl.handle.net/2263/70606 |