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The automated flow synthesis of fluorine containing organic compounds
Thesis (PhD)--University of Pretoria, 2019.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2019
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| _version_ | 1867613453215072256 |
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| access_status_str | Open Access |
| author2 | Riley, Darren Lyall |
| author_browse | Riley, Darren Lyall |
| author_facet | Riley, Darren Lyall |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD)--University of Pretoria, 2019. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/72680 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:23.211Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/72680 The automated flow synthesis of fluorine containing organic compounds Riley, Darren Lyall u04319494@tuks.co.za Scholtz, Chantal UCTD Thesis (PhD)--University of Pretoria, 2019. Fluorine has a rich history, spanning as far back as the 16th century in which mineral fluorides were first recognized, up to current times where it is frequently used in the pharmaceutical industry. The incorporation of fluorine within a molecule has the ability to modify the pharmacokinetic as well as physiochemical properties of that compound. This means that the presence of fluorine can have a profound impact on the nature and functioning of a drug. As a result of these properties of fluorine it has been incorporated in many successful drugs such as Prozac, Lipitor, Celebrex (celecoxib) and numerous anti-cancer agents. However, the incorporation of fluorine is not always simple, which has resulted in the development of a number of different fluorinating agents and fluorinating processes. Flow chemistry is the newest addition to this ever-evolving field, allowing for more efficient syntheses with substantially improved safety profiles and yields. Chemistry PhD Unrestricted 2019-12-13T08:07:29Z 2019-12-13T08:07:29Z 2019/09/05 2019 Thesis Scholtz, C 2019, The automated flow synthesis of fluorine containing organic compounds, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/72680> S2019 http://hdl.handle.net/2263/72680 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD The automated flow synthesis of fluorine containing organic compounds |
| title | The automated flow synthesis of fluorine containing organic compounds |
| title_full | The automated flow synthesis of fluorine containing organic compounds |
| title_fullStr | The automated flow synthesis of fluorine containing organic compounds |
| title_full_unstemmed | The automated flow synthesis of fluorine containing organic compounds |
| title_short | The automated flow synthesis of fluorine containing organic compounds |
| title_sort | automated flow synthesis of fluorine containing organic compounds |
| topic | UCTD |
| url | http://hdl.handle.net/2263/72680 |