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Oxygen deprivation state as a marker for the severity of obstructive sleep apnea
Thesis (PhD (Human Physiology))--University of Pretoria, 2020.
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University of Pretoria
2020
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| _version_ | 1867613584405561344 |
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| access_status_str | Open Access |
| author2 | Du Toit, Peet J. |
| author_browse | Du Toit, Peet J. |
| author_facet | Du Toit, Peet J. |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Human Physiology))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/75755 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:38:28.311Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/75755 Oxygen deprivation state as a marker for the severity of obstructive sleep apnea Du Toit, Peet J. juan.jvnn@gmail.com Van Schoor, Albert-Neels Bester, Janette Janse van Nieuwenhuizen, Juan Lodiwicus Human Physiology UCTD Health sciences theses SDG-03 Health sciences theses SDG-17 Thesis (PhD (Human Physiology))--University of Pretoria, 2020. Introduction Sleep apnea is classified as a sleep disorder characterized by a complete cessation, known as apneas, or impairment (partial cessation) of breathing, known as hypopneas. During obstructive sleep apnea (OSA), the airways become blocked, mostly due to the collapsing of the throat muscles or increased adipose tissue surrounding the airway. Apneas/hypopneas indirectly lead to the over-activity of the sympathetic nervous system. These events lead to a very interrupted sleep pattern and architecture. The most common symptoms of OSA are excessive daytime sleepiness, morning headaches and concentration problems. OSA may lead to various other disorders such as hypertension, diabetes mellitus, depression and heart failure when not treated. Limited research on OSA has been done in developing countries such as South Africa due to limited resources, funding and/or facilities. It is therefore critical that this disorder be studied in specific populations to establish more accurate parameters and normative values for clinicians to diagnose as well as treat the disorder. Methods A total of 160 patients that had suspected OSA, were referred to a private practice of clinical neurophysiology (B. Tjallinks) by their respective physicians. They were subsequently admitted at a sleep laboratory, based in Pretoria, for a single night to test for the disorder. Full polysomnography (PSG) was used to monitor the patients’ sleep. Various information such as the desaturation index, amount of obstructive sleep apneas/hypopneas, sleep architecture and baseline oxygen-haemoglobin saturation were interpreted from the test. This information was then used to assess the severity of the disorder in the patients. The PSG data were then compared with other aspects of the patient such as BMI, medical history and questionnaires. Results The oxygen deprivation state (ODS) and the apnea-hyponea index (AHI) were compared with many variables tested during the polysomnogram and it was found that ODS correlated stronger with the majority. The most important independent variables to test for hypoxia in this study was baseline SpO2, minimum SpO2, average desaturation and average duration of events. AHI was correlated (Pearson correlation coefficients) with the baseline SpO2 (-0.4463, weak), minimum SpO2 (-0.4716, weak), average desaturation (0.6701, moderate) and average duration of events (0.3262, weak). ODS was correlated (Pearson correlation coefficients) with the baseline SpO2 (-0.4524, weak), minimum SpO2 (-0.4820, weak), average desaturation (0.7524, strong) and average duration of events (0.5740, moderate). The ODS correlated stronger, even though mildly in some parameters, with all critical variables tested for the severity of hypoxic crisis in OSA. Conclusion Based on all the study objectives and results, the ODS was able to correlate stronger with the critical polysomnography variables for hypoxia and thus has proven to be a better estimate of hypoxic crisis in the severity of obstructive sleep apnea. A raw grading scale was developed based on the results of this study and are as follows: Normal (ODS ≤ 2.0%), mild (2.0% < ODS ≤ 7.7%), moderate (7.7% < ODS ≤ 17.9%) and severe (ODS > 17.9%). em2026 Physiology PhD (Human Physiology) Restricted SDG-03: Good health and well-being SDG-17: Partnerships for the goals 2020-08-14T16:19:05Z 2020-08-14T16:19:05Z 2020-08-14 2020 Thesis Janse van Nieuwenhuizen, JL 2020, Oxygen deprivation state as a marker for the severity of obstructive sleep apnea, PhD (Human Physiology) Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/75755> http://hdl.handle.net/2263/75755 © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Human Physiology UCTD Health sciences theses SDG-03 Health sciences theses SDG-17 Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title | Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title_full | Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title_fullStr | Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title_full_unstemmed | Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title_short | Oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| title_sort | oxygen deprivation state as a marker for the severity of obstructive sleep apnea |
| topic | Human Physiology UCTD Health sciences theses SDG-03 Health sciences theses SDG-17 |
| url | http://hdl.handle.net/2263/75755 |