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Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii
Thesis (PhD (Plant Sciences))--University of Pretoria, 2020.
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University of Pretoria
2020
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| _version_ | 1867613662908252160 |
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| access_status_str | Open Access |
| author2 | Tshikalange, T.E. (Thilivhali Emmanuel) |
| author_browse | Tshikalange, T.E. (Thilivhali Emmanuel) |
| author_facet | Tshikalange, T.E. (Thilivhali Emmanuel) |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Plant Sciences))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/76443 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:43.129Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/76443 Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii Tshikalange, T.E. (Thilivhali Emmanuel) fatimah.awwal@gmail.com Bapela, Mahwahwatse Johanna Lawal, Fatimah UCTD Anti-inflammatory Medicinal plants Sexually transmitted infections 1H NMR-based metabolomics of Lannea schweinfurthii Anti-inflammatory activities Traditional medicine Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 Thesis (PhD (Plant Sciences))--University of Pretoria, 2020. Inflammation and pain are major clinical signs of sexually transmitted infections (STIs) such as gonorrhoea, chlamydia, trichomoniasis, bacterial vaginosis and more recently, Mycoplasma genitalium. Delayed treatment of underlying infections often results in genital inflammation, genital ulcers, reproductive complication and an increased risk of human immunodeficiency virus (HIV) acquisition. South Africa has one of the highest rates of STIs globally and the current challenges with treatment are the issues of new infections, re-infection and multidrug resistant pathogens. Non-steroidal anti-inflammatory drugs (NSAIDs) are prescribed as part of the treatment regimen for pain and inflammation associated with STIs but their prolonged use has several undesirable side effects. This has necessitated the continuous search for suitable alternatives to existing therapeutics. Twelve South African medicinal plants used by traditional folklores in the management of STIs were screened for their anti-inflammatory activity against some inflammatory markers and their role as free radical scavenger was also assessed. Noteworthy anti-inflammatory and anti-oxidant activity with no cytotoxic effect was observed in most of the extracts. An application of proton nuclear magnetic resonance (1H NMR) and gas chromatography-mass spectroscopy (GC-MS) based metabolomics approach was used to guide the fractionation and dereplication of anti-inflammatory constituents in Lannea schweinfurthii which was the most potent inhibitor of 15-lipoxygenase (15-LOX) activity. The active fractions of L. schweinfurthii contained several bioactive phenolic compounds with known inflammatory activities and other constituents which are reported for the first time from this plant. The findings from this study reveals the anti-inflammatory potential of active plants as new sources of compounds which can be further explored for the management of STI related inflammation. The metabolomic approach and dereplication techniques employed in this study facilitated the identification of bioactive compounds and prevented the re-isolation of already known compounds and thus, facilitates the speedy discovery of novel compounds from plants. National Research Foundation (NRF) bs2026 Plant Science PhD (Plant Sciences) Unrestricted SDG-03: Good health and well-being SDG-09: Industry, innovation and infrastructure SDG-15: Life on land 2020-10-12T08:13:11Z 2020-10-12T08:13:11Z 2020-09 2020 Thesis Lawal, F 2020, Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii, PhD (Plant Sciences) Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/76443> http://hdl.handle.net/2263/76443 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Anti-inflammatory Medicinal plants Sexually transmitted infections 1H NMR-based metabolomics of Lannea schweinfurthii Anti-inflammatory activities Traditional medicine Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title | Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title_full | Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title_fullStr | Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title_full_unstemmed | Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title_short | Anti-inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1H NMR-based metabolomics of Lannea schweinfurthii |
| title_sort | anti inflammatory potential of selected medicinal plants used in the treatment of sexually transmitted infections and 1h nmr based metabolomics of lannea schweinfurthii |
| topic | UCTD Anti-inflammatory Medicinal plants Sexually transmitted infections 1H NMR-based metabolomics of Lannea schweinfurthii Anti-inflammatory activities Traditional medicine Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 |
| url | http://hdl.handle.net/2263/76443 |