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Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly
Dissertation (MSc (Clinical Epidemiology)--University of Pretoria, 2019.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2020
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| _version_ | 1867613613336821760 |
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| access_status_str | Open Access |
| author2 | Girdler-Brown, Brendan V. |
| author_browse | Girdler-Brown, Brendan V. |
| author_facet | Girdler-Brown, Brendan V. |
| collection | Thesis |
| dc_rights_str_mv | © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Clinical Epidemiology)--University of Pretoria, 2019. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/76776 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:55.836Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/76776 Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly Girdler-Brown, Brendan V. themofokengs@gmail.com Rapetsoa, Maropeng Innocentia Kgomotso UCTD Pneumococcal Vaccines Pneumonia Prevention Elderly Population Vaccine Effectiveness Immunization Programs Healthcare Utilization Vaccine Safety Elderly Healthcare Health sciences theses SDG-03 SDG-03: Good health and well-being Health sciences theses SDG-10 SDG-10: Reduced inequalities Dissertation (MSc (Clinical Epidemiology)--University of Pretoria, 2019. Introduction Hospitalisations and prolonged hospital stays impose great economic burden especially at the present time when resources are limited. Community-acquired pneumonia (CAP) is a common and costly illness associated with considerable morbidity and mortality. Other than children, the elderly are the most vulnerable to CAP due to reduced immunity and comorbid chronic conditions. Streptococcus pneumoniae (S. pneumoniae) has been identified as the most common culprit encountered in cases of CAP with the incidence of CAP peaking during the annual influenza season. There is a known synergistic pathogenesis between the influenza virus and S. pneumoniae. Vaccination against invasive pneumococcal disease (IPD) is established in children. However, the burden of pneumonia has remained high in the elderly. This study sought to explore primarily the effectiveness of pneumococcal vaccination, as administered in a South African Medical scheme population, in the elderly who are aged 65 years and older; and secondly to explore the effectiveness of influenza vaccination in the same age group in preventing hospital admissions due to pneumonia (all causes). Methods The study population consisted of 34 068 beneficiaries of Medihelp medical aid scheme, and the outcome measures were investigated for years 2017/2018. The researcher has conducted a case-control study using cross-sectional secondary data with 1:1 matching. The sample size consisted of 800 pairs of case and control for primary and secondary exposures (pneumococcal vaccine and influenza vaccine, respectively). ICD-10 (International classification of diseases .10th revision) coding was used to identify study cases based on hospital admission claims and was matched for covariates age, sex and important comorbidities: ischaemic heart disease (IHD), chronic obstructive pulmonary disease (COPD), asthma and diabetes mellitus (DM). For the primary outcome, we adjusted for the use of influenza vaccine and for the secondary outcome, we adjusted for the use of pneumococcal vaccine. McNemar’s odds ratio (OR) and its 95% confidence interval (CI) was used to measure the association between vaccination and hospitalisation for CAP. Sensitivity analyses by means of propensity score matching (PSM) were also performed to estimate the OR. In addition, subgroup analyses were performed by estimating the odds ratios in participants who have used 23-valent pneumococcal polysaccharide vaccine (PPSV-23) and 13-valent pneumococcal conjugate vaccine (PCV-13) respectively for the primary exposure by PSM. Results All participants had claimed only one type of pneumococcal vaccine in this study. Vaccine uptake for pneumococcal vaccine and influenza vaccine in the study population were 0.9% and 16.6% respectively. For the primary exposure, 15 (1.9%) cases were exposed to pneumococcal vaccine compared to nine (1.1%) in controls with an OR of 1.67 (95% confidence interval (CI), 0.683 - 4.319) (P= 0.308). Propensity score matching revealed similar estimates, although closer to the null value, with OR of 1.05 (95% CI, 0.991 - 1.121) (P= 0.095). For the secondary exposure, 140 (17.5%) cases were exposed to influenza vaccination compared to 152 (19.0%) controls with an OR of 0.90 (95% CI, 0.683 - 1.178) with a (P= 0.460). Using PSM the OR was 0.99 (95% CI, 0.983 - 0.994) (P<0.001). Conclusions In order to enhance the vaccine effectiveness (VE) of pneumococcal vaccine, it is recommended that sequential vaccination with a dose of PCV-13 to be followed by a dose of PPSV-23 one year later in all adults 65 years and older. Once off vaccination with either type of pneumococcal vaccine did not confer a protective benefit in this study. This recommendation is based on guidelines in use for South Africa and other international agencies. Compliance with the guidelines vaccination schedule was found not to be the practice in our study population. For the secondary exposure, our findings reaffirm the significance of seasonal influenza vaccination for the study age cohort. We recommend that programmes to significantly enhance both pneumococcal and influenza vaccine uptake be earnestly addressed in order to address severe uptake deficiencies observed in this study. Both vaccines should be given concurrently in order to enhance compliance and to further reduce the burden of CAP for the study age cohort. em2025 Clinical Epidemiology MSc (Clinical Epidemiology) Unrestricted SDG-03: Good health and well-being SDG-10: Reduced inequalities 2020-11-04T15:09:51Z 2020-11-04T15:09:51Z 20/05/08 2019 Dissertation Rapetsoa, MIK 2019, Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly, MSc (Clinical Epidemiology) Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/76776> A2020 http://hdl.handle.net/2263/76776 en © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Pneumococcal Vaccines Pneumonia Prevention Elderly Population Vaccine Effectiveness Immunization Programs Healthcare Utilization Vaccine Safety Elderly Healthcare Health sciences theses SDG-03 SDG-03: Good health and well-being Health sciences theses SDG-10 SDG-10: Reduced inequalities Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title | Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title_full | Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title_fullStr | Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title_full_unstemmed | Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title_short | Effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| title_sort | effectiveness of pneumococcal vaccine in preventing hospital admissions for pneumonia among the elderly |
| topic | UCTD Pneumococcal Vaccines Pneumonia Prevention Elderly Population Vaccine Effectiveness Immunization Programs Healthcare Utilization Vaccine Safety Elderly Healthcare Health sciences theses SDG-03 SDG-03: Good health and well-being Health sciences theses SDG-10 SDG-10: Reduced inequalities |
| url | http://hdl.handle.net/2263/76776 |