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Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa
Dissertation (MSc)--University of Pretoria, 2019.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2020
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| _version_ | 1867613688916082688 |
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| access_status_str | Open Access |
| author2 | Crafford, Jan Ernst |
| author_browse | Crafford, Jan Ernst |
| author_facet | Crafford, Jan Ernst |
| collection | Thesis |
| dc_rights_str_mv | © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2019. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/76863 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:07.894Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/76863 Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa Crafford, Jan Ernst u26222028@tuks.co.za Guthrie, Alan John Jacobs, Nicholaas Hendrik UCTD Dissertation (MSc)--University of Pretoria, 2019. Recent case reports have suggested an increase in cases where dogs have been affected by African horse sickness virus (AHSV). Contrary to historic findings, several cases have been reported where dogs became infected without any evidence of contact with or consumption of infected horses or their products. This was a prospective study to determine the prevalence of specific antibody and nucleic acid to AHSV and Equine encephalosis virus (EEV) in a high risk, isolated dog population during the high vector period in an endemic area. Dogs were kept in open kennels in close proximity to horses, sheep and cattle. Dogs in this population have historically been diagnosed with clinical AHS. Blood samples were collected on a monthly interval from February to June 2019. Antibody to AHSV was detected using an indirect ELISA while antibody to EEV was detected using a competitive ELISA. Infection rates were determined by demonstrating viral nucleic acids by RTqPCR. All of the 37 sampled dogs remained negative for RNA to both AHSV and EEV for the duration of the study. This indicates that there were no equine orbiviruses circulating in this dog population and is consistent with the absence of any clinical signs during the study period. This is also in line with the absence of any new AHS case reports in dogs from the area. Low levels of antibody were detected at some time points indicating transient exposure without viremia or due to crossreactions with unknown antigens. Veterinary Tropical Diseases MSc Unrestricted 2020-11-04T15:10:11Z 2020-11-04T15:10:11Z 20/04/22 2019 Dissertation Jacobs, NH 2019, Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa, MSc Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/76863> A2020 http://hdl.handle.net/2263/76863 en © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title | Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title_full | Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title_fullStr | Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title_full_unstemmed | Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title_short | Seroprevalence and infection rates for equine orbivirus infections in dogs at Onderstepoort, South Africa |
| title_sort | seroprevalence and infection rates for equine orbivirus infections in dogs at onderstepoort south africa |
| topic | UCTD |
| url | http://hdl.handle.net/2263/76863 |