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A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review
Dissertation (MA (Audiology))--University of Pretoria, 2020.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2020
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| _version_ | 1867613500808888320 |
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| access_status_str | Open Access |
| author2 | Soer, Maggi E. (Magdalena Elizabeth) |
| author_browse | Soer, Maggi E. (Magdalena Elizabeth) |
| author_facet | Soer, Maggi E. (Magdalena Elizabeth) |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MA (Audiology))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/77019 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:08.629Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/77019 A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review Soer, Maggi E. (Magdalena Elizabeth) larrainev377@gmail.com Heinze, Barbara M. Botha, Larraine UCTD Audiology Dissertation (MA (Audiology))--University of Pretoria, 2020. Objective: This study aimed to examine the current available peer-reviewed evidence in order to gain insight into the most effective procedures used for the early identification and monitoring of aminoglycoside (AG)-induced cochleotoxicity and to suggest a protocol based on these findings. Method: Several databases were sourced with a comprehensive search conducted on Pubmed, Scopus and Medline (Ovid) to identify peer-reviewed studies published in English up until March 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were adhered to. Studies were subjected to pre-set inclusion and exclusion criteria in order to eliminate the possibility of effects other than AG/s influencing auditory functioning. The reference lists of the included studies were also screened. Results: Twenty-one studies met the inclusion criteria for the systematic review and were analysed. The majority of the studies used conventional pure tone audiometry (PTA) with only a few studies using extended high frequencies (EHF/s) and otoacoustic emission (OAE) testing. Conclusion: Since the damaging effect of AG/s is evident at the outer hair cells (OHC/s) of the basal end of the cochlea first, EHF audiometry and distortion product otoacoustic emissions (DPOAE/s) testing seems more promising for the early detection and monitoring of AG-induced cochleotoxicity. For effective and efficient identification and monitoring of AG-induced cochleotoxicity, a test battery comprising of a combination of subjective and objective measures, specifically aimed at the OHC/s by means of EHF audiometry and OAE-testing (DPOAE specifically) and possibly speech-in-noise (SPIN) tests such as the digits-in-noise (DIN) / SPIN-tests, is recommended as a standard protocol. Speech-Language Pathology and Audiology MA (Audiology) Unrestricted 2020-11-16T08:29:09Z 2020-11-16T08:29:09Z 2020 2020 Dissertation Botha, L 2020, A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review, MA (Audiology) Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/77019> http://hdl.handle.net/2263/77019 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Audiology A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title | A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title_full | A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title_fullStr | A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title_full_unstemmed | A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title_short | A protocol for the identification and monitoring of aminoglycoside-induced cochleotoxicity : a systematic literature review |
| title_sort | protocol for the identification and monitoring of aminoglycoside induced cochleotoxicity a systematic literature review |
| topic | UCTD Audiology |
| url | http://hdl.handle.net/2263/77019 |