Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs
Dissertation (MMedVet (Pathology))--University of Pretoria, 2019.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2020
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613506260434944 |
|---|---|
| access_status_str | Open Access |
| author2 | Leisewitz, Andrew L. |
| author_browse | Leisewitz, Andrew L. |
| author_facet | Leisewitz, Andrew L. |
| collection | Thesis |
| dc_rights_str_mv | © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MMedVet (Pathology))--University of Pretoria, 2019. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/77412 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:13.890Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/77412 Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs Leisewitz, Andrew L. u21075116@tuks.co.za Clift, Sarah J. Martin, Collin Armand UCTD Canine babesiosis Acute lung injury (ALI) Tick-borne disease Hypoxaemia Tick vectors Veterinary science theses SDG-02 Veterinary science theses SDG-03 Veterinary science theses SDG-15 Dissertation (MMedVet (Pathology))--University of Pretoria, 2019. A proportion of Babesia rossi infections in dogs are classified as complicated. One of the most lethal complications is the acute lung injury (ALI) and acute respiratory destress syndrome (ARDS). Patients affected by this complication usually succumb within 24 hours and there are similarities between this disease and malaria associated ALI and ARDS in humans, both rapidly fatal conditions. Both diseases are caused by haemoprotozoal parasites transmitted by insect vectors, namely ticks for babesiosis and mosquitoes for malaria. The pulmonary pathology of complicated babesiosis is poorly described and the aim of this study is to provide a thorough histomorphological analysis with immunohistochemical labelling of leukocytes to further define the immune cell population. The left caudal lung lobes from 11 Babesia rossi infected dogs and 4 healthy controls were examined with standard light microscopy and immunohistochemical markers applied. Markers included CD204 (resident tissue macrophages and dendritic cells), MAC387 (monocyte-macrophages of bone marrow origin), CD3 (mature T-lymphocytes), CD20 (mature B-lymphocytes and normal plasma cells), Mum-1 (plasma cells) and PAX-5 (immature and mature B-lymphocytes). Histopathology showed a severe increase in monocyte-macrophages within the alveolar walls and lumens. This was invariably accompanied by alveolar oedema as well as multifocal to coalescing areas of haemorrhage. Immunohistochemical labelling showed a significant increase in MAC387, CD204 and CD3 positive cells in the infected cases compared to healthy control dogs. This study provided novel insights into the pathology of and similarities between babesia and malaria associated ALI/ARDS in dogs and humans, respectively. Further fine ultrastructural examination of the pulmonary vascular endothelium is required in future studies. es2026 Paraclinical Sciences MMedVet (Pathology) Unrestricted SDG-02: Zero hunger SDG-03: Good health and well-being SDG-15: Life on land 2020-12-21T09:53:39Z 2020-12-21T09:53:39Z 2020/09/30 2020 Dissertation Martin, CA 2020, Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs, MMedVet (Pathology) Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/77412> S2020 http://hdl.handle.net/2263/77412 en © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Canine babesiosis Acute lung injury (ALI) Tick-borne disease Hypoxaemia Tick vectors Veterinary science theses SDG-02 Veterinary science theses SDG-03 Veterinary science theses SDG-15 Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title | Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title_full | Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title_fullStr | Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title_full_unstemmed | Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title_short | Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs |
| title_sort | pathology of complicated babesia rossi associated acute lung injury and respiratory distress syndrome in dogs |
| topic | UCTD Canine babesiosis Acute lung injury (ALI) Tick-borne disease Hypoxaemia Tick vectors Veterinary science theses SDG-02 Veterinary science theses SDG-03 Veterinary science theses SDG-15 |
| url | http://hdl.handle.net/2263/77412 |