Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval)
Dissertation (MSc (Veterinary Science))--University of Pretoria, 2019.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2020
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613647508865024 |
|---|---|
| access_status_str | Open Access |
| author2 | Zeiler, Gareth Edward |
| author_browse | Zeiler, Gareth Edward |
| author_facet | Zeiler, Gareth Edward |
| collection | Thesis |
| dc_rights_str_mv | © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Veterinary Science))--University of Pretoria, 2019. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/77438 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:28.478Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/77438 Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) Zeiler, Gareth Edward Steenkamp, Gerhardus Blignaut, Christiaan Johannes UCTD Veterinary science theses SDG-15 SDG-15: Life on land Dissertation (MSc (Veterinary Science))--University of Pretoria, 2019. Objective To compare ketamine-butorphanol-medetomidine (KBM) to butorphanolmidazolam- medetomidine (BMM) for chemical capture (immobilisation) of serval (Leptailurus serval). Study design Blinded, randomised immobilisation trial. Animals 23 free-ranging captures (KBM: 5 females, 6 males; mean weight 10.7 kg; BMM: 10 females, 2 males; mean weight 9.6 kg). Methods Free-ranging serval were cage trapped and then immobilised using the randomly assigned drug combination delivered via a blow dart into the gluteal muscles. Prior to darting, a stress score was assigned (0: Calm; to 3: markedly stressed). The drug combinations were dosed based on estimated body weights: KBM - 8.0, 0.4 and 0.08 mg kg-1, respectively; BMM - 0.4, 0.3 and 0.08 mg kg-1, respectively. Time to first handling, duration of anaesthesia and recovery times were recorded. Physiological variables were recorded at five-minute intervals and arterial blood was sampled 20 minutes after instrumentation for arterial blood gas analysis. Atipamezole (5 mg kg-1 medetomidine) and naltrexone (2 mg kg-1 butorphanol) were administered intramuscularly for recovery. Data, presented using mean ± standard deviation values, were analysed using student t-test, general linear mixed model and Spearman’s rank correlation. Results The dose based on actual body weights were 8.7 ± 1.5, 0.4 ± 0.08 and 0.09 ± 0.02 mg kg-1 for KBM; and 0.5 ± 0.07, 0.4 ± 0.01 and 0.09 ± 0.05 mg kg-1 for BMM. Time to first handling was 611 ± 165 seconds for KBM and 800 ± 228 seconds for BMM (p = 0.033). Both combinations produced a physiological stable immobilisation that lasted for at least 35 minutes. Recovery was rapid and calm overall, but ataxia was noted in KBM. Stress score was positively and strongly correlated to blood glucose (r2 = 0.788; p = 0.001) and temperature (r2 = 0.634; p = 0.015). Conclusion and clinical relevance Both combinations produce similar effective immobilisation that were physiologically stable in serval. Overall, BMM is recommended because it is fully antagonisable. It is essential to provide a calm, quiet environment before drug administration to avoid capture-induced hyperglycaemia and hyperthermia. Companion Animal Clinical Studies MSc (Veterinary Science) Unrestricted 2020-12-21T09:53:45Z 2020-12-21T09:53:45Z 2020/09/30 2020 Dissertation Blignaut, CJ 2020, Ketamine-butorphanol-medetomidine versus butorphanolmidazolam-medetomidine immobilisation of serval (Leptailurus serval), MSc (Veterinary Science) Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/77438> S2020 http://hdl.handle.net/2263/77438 en © 2020 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Veterinary science theses SDG-15 SDG-15: Life on land Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title | Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title_full | Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title_fullStr | Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title_full_unstemmed | Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title_short | Ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine immobilisation of serval (Leptailurus serval) |
| title_sort | ketamine butorphanol medetomidine versus butorphanol midazolam medetomidine immobilisation of serval leptailurus serval |
| topic | UCTD Veterinary science theses SDG-15 SDG-15: Life on land |
| url | http://hdl.handle.net/2263/77438 |