Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs
Dissertation (MSc (Chemical Pathology))--University of Pretoria, 2020.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2021
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613435550760960 |
|---|---|
| access_status_str | Open Access |
| author2 | Pillay, Tahir S. |
| author_browse | Pillay, Tahir S. |
| author_facet | Pillay, Tahir S. |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Chemical Pathology))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/79321 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:06.245Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/79321 Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs Pillay, Tahir S. charlesmatamela@gmail.com Mabugana, Matamela Charles UCTD Insulin resistance HAART CRISPR-Cas9 NFkB Diabetes HIV/AIDS treatment Antiretroviral drugs Insulin resistance Nuclear factor-Kappa B (NF-κB) Cytokines Adipose tissue Immune response Health sciences theses SDG-03 SDG-03: Good health and well-being Dissertation (MSc (Chemical Pathology))--University of Pretoria, 2020. Human immunodeficiency virus still remains the leading cause of death globally including women of child-bearing age. The rate of AIDS-related death has significantly declined since the introduction of antiretroviral treatment and other non-medical interventions such as the distribution and use of condoms. The introduction of antiretroviral treatment has however led to insulin resistance amongst users. Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated nuclease 9 (Cas) has been used to knockout NFκB to understand the pathway at which antiretroviral treatment causes insulin resistance. Heteroduplex mobility assay has shown that CRISPR-Cas9 knock out the gene of interest. These results have played a foundation in understanding how CRISPR-Cas9 can be integrated and utilized in medical research. National Research Foundation (NRF) em2026 Chemical Pathology MSc (Chemical Pathology) Restricted SDG-03: Good health and well-being 2021-04-06T11:34:20Z 2021-04-06T11:34:20Z 2021-04-16 2020 Dissertation Mabugana, MC 2020, Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs, MSc (Chemical Pathology) Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/79321> A2021 http://hdl.handle.net/2263/79321 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Insulin resistance HAART CRISPR-Cas9 NFkB Diabetes HIV/AIDS treatment Antiretroviral drugs Insulin resistance Nuclear factor-Kappa B (NF-κB) Cytokines Adipose tissue Immune response Health sciences theses SDG-03 SDG-03: Good health and well-being Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title | Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title_full | Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title_fullStr | Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title_full_unstemmed | Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title_short | Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs |
| title_sort | analysis of the role of nuclear factor kappa b in insulin resistance caused by antiretroviral drugs |
| topic | UCTD Insulin resistance HAART CRISPR-Cas9 NFkB Diabetes HIV/AIDS treatment Antiretroviral drugs Insulin resistance Nuclear factor-Kappa B (NF-κB) Cytokines Adipose tissue Immune response Health sciences theses SDG-03 SDG-03: Good health and well-being |
| url | http://hdl.handle.net/2263/79321 |