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The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds
Thesis (PhD (Chemistry))--University of Pretoria, 2021.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2021
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| _version_ | 1867613680027303936 |
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| access_status_str | Open Access |
| author2 | Pilcher, Lynne A. |
| author_browse | Pilcher, Lynne A. |
| author_facet | Pilcher, Lynne A. |
| collection | Thesis |
| dc_rights_str_mv | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Chemistry))--University of Pretoria, 2021. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83047 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:59.298Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83047 The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds Pilcher, Lynne A. u17405832@tuks.co.za Balogun, Mohammed Mvango, Sindisiwe Malaria Polymer-drug conjugation Polymer therapuetics UCTD Thesis (PhD (Chemistry))--University of Pretoria, 2021. Malaria continues to be a major infectious disease with 229 million cases reported in 2019 of which 94% occurred in the African region. Problems such as poor aqueous solubility, instability, toxicity and drug resistance hamper the efficacy of antimalarial drugs recommended by World Health Organization. Polymer therapeutics is a nanomedicine technology platform that has seen limited application to malaria and other infectious diseases. In this work, chemistry was developed for linking hydrophobic compounds used for the treatment of malaria (betulinic acid, dihydroartemisinin, lumefantrine, and primaquine) to hydrophilic polymers (polyethylene glycol, chitosan, poly(N-acryloylmorpholine) macromonomers-co-acrylic acid and polyglutamic acid). Analysis revealed how conjugationto the polymers resulted in polymer therapeutics with physico-chemical properties markedly different from the original drugs. The most clinically significant changes demonstrated were improved solubility and reduced toxicity. By developing synthetic chemical routes to these antimalarial polymer therapeutics with enhanced aqueous solubility, this work opens up the possibility of the development of intravenous triple combination therapies for patients with severe or complicated malaria and for blocking transmission. NRF/CSIR PDP program. National Research Foundation of South Africa (Grant 105942). Chemistry PhD (Chemistry) Unrestricted 2021-12-14T07:21:10Z 2021-12-14T07:21:10Z 2022-04-05 2021 Thesis * A2022 http://hdl.handle.net/2263/83047 en © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Malaria Polymer-drug conjugation Polymer therapuetics UCTD The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title | The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title_full | The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title_fullStr | The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title_full_unstemmed | The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title_short | The chemical syntheses and physico-chemical characterization of polymer conjugates of antimalarial compounds |
| title_sort | chemical syntheses and physico chemical characterization of polymer conjugates of antimalarial compounds |
| topic | Malaria Polymer-drug conjugation Polymer therapuetics UCTD |
| url | http://hdl.handle.net/2263/83047 |