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Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs
Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613592819335168 |
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| access_status_str | Open Access |
| author2 | Jonker, Annelize |
| author_browse | Jonker, Annelize |
| author_facet | Jonker, Annelize |
| collection | Thesis |
| dc_rights_str_mv | © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83259 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:35.948Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83259 Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs Jonker, Annelize u17388555@tuks.co.za Manatsa, Samson UCTD antimicrobial resistance Escherichia coli prevalence TEM gene Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020. Emerging extended-spectrum beta lactamase (ESBL) Escherichia coli in veterinary and human medicine is a global threat to health delivery. This study investigated the presence and prevalence of ESBL producers from diagnostic isolates. The isolates were characterised through retrospective analysis of existing Kirby-Bauer results to determine the phenotypic resistance prevalence and screen for ESBL producing isolates, to quantify resistance through the M.I.C.E test and detect the TEM gene. A total of 36 isolates out of 37 were ESBL producers and 10 isolates were carrying the TEM gene. Retrospective analysis demonstrated varying resistance prevalence from 5.4 to as high as75.7% against the 15 antibiotics across all 37 isolates. Resistance across all 37 isolates was observed with a prevalence of 78.4% against ampicillin, 54.1% against amoxicillin / clavulanic acid, 21.6% against ceftazidime and 24.6% against cefotaxime but no resistance was observed against imipenem. Resistance was also observed in some isolates which were negative for the TEM gene. Further investigation to identify the other ESBL genes causing the resistance phenotype observed in E. coli isolates which tested negative for the TEM gene is needed. Veterinary Tropical Diseases MSc (Tropical Animal Health) Unrestricted 2022-01-12T06:00:55Z 2022-01-12T06:00:55Z 2021/04/16 2020 Mini Dissertation * A2021 http://hdl.handle.net/2263/83259 en © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD antimicrobial resistance Escherichia coli prevalence TEM gene Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title | Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title_full | Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title_fullStr | Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title_full_unstemmed | Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title_short | Antimicrobial resistance patterns and ESBL producers among Escherichia coli isolates from dogs |
| title_sort | antimicrobial resistance patterns and esbl producers among escherichia coli isolates from dogs |
| topic | UCTD antimicrobial resistance Escherichia coli prevalence TEM gene |
| url | http://hdl.handle.net/2263/83259 |