Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs
Dissertation (MSc)--University of Pretoria, 2020.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2022
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613671215071232 |
|---|---|
| access_status_str | Open Access |
| author2 | Zeiler, Gareth Edward |
| author_browse | Zeiler, Gareth Edward |
| author_facet | Zeiler, Gareth Edward |
| collection | Thesis |
| dc_rights_str_mv | © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc)--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83263 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:51.199Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83263 Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs Zeiler, Gareth Edward u29019550@tuks.co.za Buck, Roxanne Kate Boustead, Keagan John UCTD Dissertation (MSc)--University of Pretoria, 2020. Objective To compare the effect of invasive continuous positive airway pressure (CPAP), pressure-controlled ventilation with positive end expiratory pressure (PCV+PEEP) and spontaneous breathing (SB) on carbon dioxide removal, blood oxygenation and indicators of tissue perfusion in healthy anaesthetised dogs. Study design Prospective randomised crossover study. Animals Fifteen intact male dogs of various breeds of mean (± standard deviation) age and weight of 25 (± 19) months and 21.7 (± 9.9) kg, respectively. Methods Dogs were anaesthetised (buprenorphine, medetomidine, propofol) and maintained with isoflurane in 50% oxygen-air mixture and kept in right lateral recumbency. Ventilation treatments (CPAP: 4 cmH2O; PCV+PEEP: 10 cmH2O peak inspiratory pressure, 4 cmH2O positive end-expiratory pressure, respiratory rate of 10 breaths minute-1 and inspiratory-to-expiratory ratio of 1:2; SB: standard circle circuit, no pressure applied) were administered to each dog consecutively in random order under the same anaesthetic period with 5-minute SB washout period between treatments. Arterial and central venous blood samples for gas analysis were collected at the start (0 minutes) and end (20 minutes) of each ventilation treatment. Arterial to venous content difference was calculated for each ventilatory treatment. Other physiological variables and spirometry measures were collected at 5-minute intervals from start to end for each ventilation treatment. Data was compared using a general linear mixed model (p < 0.05). Results Arterial oxygen tension was significantly higher and carbon dioxide tension lower after PCV+PEEP than CPAP and SB (all: p < 0.001), but no different between CPAP and SB (p =1.000 and p = 0.697 respectively). Central venous oxygen and carbon dioxide tensions were significantly lower after PCV+PEEP compared to SB and CPAP (all: p < 0.001). The tidal volume and minute volume were higher during PCV+PEEP than during SB and CPAP (both: p < 0.001). Arterial-venous oxygen content difference was higher with PCV+PEEP compared to SB and CPAP (both: p < 0.001). Conclusion and clinical relevance. An increased tidal volume with PCV+PEEP resulted in improved arterial oxygenation and carbon dioxide elimination as compared to CPAP and SB. CPAP resulted in similar oxygenation and ventilation to SB. Increased oxygen extraction occurred with PCV+PEEP, probably associated with a reduced cardiac output. The clinical benefit of short-term invasive CPAP over SB in the healthy anaesthetised dog remains uncertain. Companion Animal Clinical Studies MSc Unrestricted 2022-01-12T06:00:57Z 2022-01-12T06:00:57Z 2021/04/16 2020 Dissertation * A2021 http://hdl.handle.net/2263/83263 en © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title | Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title_full | Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title_fullStr | Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title_full_unstemmed | Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title_short | Cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| title_sort | cardiopulmonary effects of three different ventilation treatments in healthy anaesthetised dogs |
| topic | UCTD |
| url | http://hdl.handle.net/2263/83263 |