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Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis
Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613623271030784 |
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| access_status_str | Open Access |
| author2 | Michel, Anita Luise |
| author_browse | Michel, Anita Luise |
| author_facet | Michel, Anita Luise |
| collection | Thesis |
| dc_rights_str_mv | © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83282 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:05.410Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83282 Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis Michel, Anita Luise u19394901@tuks.co.za Phiri, Chadzantso UCTD Mini Dissertation (MSc (Tropical Animal Health))--University of Pretoria, 2020. The International Standard Bovine Tuberculin (ISBT) was confirmed for use in 1986 and serves as an internationally accepted reference for calibration and quality control. The World Health Organization has been involved in the production of a standard bovine tuberculin since 1976. More recently, the OIE in collaboration with the WHO coordinated a project for the development and testing of a new ISBT. By means of the international collaborative study, the performance of the ISBT against two new candidate tuberculins A and B, at two different concentrations in different regions of the world was tested. This study formed part of this international collaboration and tested the performance of the candidate tuberculins A (CA-1; 0.02mg, CA-2; 0.1mg) and B (CB-1; 0.02mg, CB-2; 0.1mg) in naturally infected cattle in South Africa. In order to test the performance of the candidate tuberculins A and B and the ISBT, 130 animals from known bovine tuberculosis positive herds were sampled. The BOVIGAMTM assay was used to identify 24 animals from the 130 animals, that were bovine tuberculosis positive and these animals were selected for the intradermal tuberculin testing. Evaluation of the performance of candidate tuberculins was done by comparing the skin test reactions of the tuberculins with the skin test reactions of the current ISBT. The means of the skin fold increases in the ISBT was compared to the means of the skin fold increases in candidates A and B. These were compared using ANOVA in excel analysis package, and the results indicated that there was no significant difference between the ISBT and the candidates A and B. The different concentrations in the tuberculins also did not register any significant difference in reactions and there was also no significant difference in the performance of the tuberculins on the different sides of the bovine neck. The clinical signs at the injection sites of both the ISBT and the candidate tuberculins were compared using ANOVA in excel analysis package and the p values were also >0.05 which indicated a lack of a significant difference between them. These results suggest that the candidate tuberculins A and B worked as effectively and gave similar skin responses to the current ISBT and may be considered for field diagnosis of bovine tuberculosis. Veterinary Tropical Diseases MSc (Tropical Animal Health) Unrestricted 2022-01-12T06:01:14Z 2022-01-12T06:01:14Z 2021/04/16 2020 Mini Dissertation * A2021 http://hdl.handle.net/2263/83282 en © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title | Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title_full | Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title_fullStr | Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title_full_unstemmed | Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title_short | Performance of two candidate bovine tuberculins in the intradermal tuberculin test in South African cattle naturally infected with Mycobacterium bovis |
| title_sort | performance of two candidate bovine tuberculins in the intradermal tuberculin test in south african cattle naturally infected with mycobacterium bovis |
| topic | UCTD |
| url | http://hdl.handle.net/2263/83282 |